G7801
Gly-Gly
98%
Synonym(s):
Diglycine, Glycyl-glycine
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About This Item
Linear Formula:
NH2CH2CONHCH2COOH
CAS Number:
Molecular Weight:
132.12
EC Number:
209-127-8
UNSPSC Code:
12161700
PubChem Substance ID:
Beilstein/REAXYS Number:
1765223
MDL number:
Product Name
Gly-Gly, 98%
InChI key
YMAWOPBAYDPSLA-UHFFFAOYSA-N
InChI
1S/C4H8N2O3/c5-1-3(7)6-2-4(8)9/h1-2,5H2,(H,6,7)(H,8,9)
SMILES string
NCC(=O)NCC(O)=O
assay
98%
form
powder
useful pH range
7.5-8.9
pKa (25 °C)
8.2
mp
255-260 °C
application(s)
peptide synthesis
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Application
Buffer useful in the physiological pH range. pKa=8.40 at 20°C. Used in peptide modeling and drug solubilizing studies.
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
Regulatory Information
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Pharmazie, 48, 552-552 (1993)
A Li et al.
Journal of pharmaceutical sciences, 83(12), 1735-1740 (1994-12-01)
The log-linear solubilization model was applied to the experimental solubility data of 109 organic compounds in ethanol/water mixtures. It is found that the extent of solubilization strongly depends on the solute hydrophobicity and the ethanol concentration in the solvent mixture.
M A Eiteman et al.
Biotechnology progress, 10(5), 513-519 (1994-09-01)
A mathematical procedure was developed to predict the partition coefficients of the peptides AIIP, AWWP, AIIPAIIP and AWWPAWWP in poly(ethylene glycol) (PEG)/phosphate aqueous two-phase systems from amino acid hydrophobicities. In general, peptides containing tryptophan partition more into the PEG-enriched upper
Namrata D Udeshi et al.
Molecular & cellular proteomics : MCP, 12(3), 825-831 (2012-12-26)
Detection of endogenous ubiquitination sites by mass spectrometry has dramatically improved with the commercialization of anti-di-glycine remnant (K-ε-GG) antibodies. Here, we describe a number of improvements to the K-ε-GG enrichment workflow, including optimized antibody and peptide input requirements, antibody cross-linking
P B Armentrout et al.
Journal of the American Society for Mass Spectrometry, 23(4), 621-631 (2011-09-29)
We present a full computational description of the fragmentation reactions of protonated diglycine (H(+)GG). Relaxed potential energy surface scans performed at B3LYP/6-31 G(d) or B3LYP/6-311 + G(d,p) levels are used to map the reaction coordinate surfaces and identify the transition states (TSs) and
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