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I3875

Indoxyl sulfate potassium salt

Name: Indoxyl sulfate potassium salt
Brand: ALDRICH

Synonym(s):

Potassium 3-indoxyl sulfate, Urinary indican

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About This Item

Linear Formula:

C₈H₆NO₄SK

CAS Number:

2642-37-7

Molecular Weight:

251.30

UNSPSC Code:

12352100

NACRES:

NA.22

PubChem Substance ID:

57654302

EC Number:

220-145-5

Beilstein/REAXYS Number:

3921324

MDL number:

MFCD00037931

Assay:

> 98 %

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Properties

assay

> 98 %

Quality Level

200

mp

165 °C (dec.) (lit.)

solubility

water: soluble

storage temp.

−20°C

SMILES string

[K+].[O-]S(=O)(=O)Oc1c[nH]c2ccccc12

InChI

1S/C8H7NO4S.K/c10-14(11,12)13-8-5-9-7-4-2-1-3-6(7)8;/h1-5,9H,(H,10,11,12);/q;+1/p-1

InChI key

MDAWATNFDJIBBD-UHFFFAOYSA-M

Description

General description

Indoxyl sulfate potassium salt is derived from indoxyl sulfate by replacing the hydrogen ion with a potassium cation. Potassium indoxyl sulfate is used as a reagent for the detection and determination of hydrogen peroxide.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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An in-vitro assay using human spermatozoa to detect toxicity of biologically active substances.

Tino Vollmer et al.

Scientific reports, 9(1), 14525-14525 (2019-10-12)

Identifying the key toxic players within an in-vivo toxic syndrome is crucial to develop targeted therapies. Here, we established a novel method that characterizes the effect of single substances by means of an ex-vivo incubation set-up. We found that primary

Indoxyl sulfate upregulates renal expression of ICAM-1 via production of ROS and activation of NF-κB and p53 in proximal tubular cells.

Hidehisa Shimizu et al.

Life sciences, 92(2), 143-148 (2012-12-04)

Intercellular adhesion molecule 1 (ICAM-1) plays an important role in adhesion of monocytes/macrophages to injured tubulointerstitial tissue. The present study aimed to determine if indoxyl sulfate, a uremic toxin, regulates renal expression of ICAM-1. The effect of indoxyl sulfate on

Indoxyl-sulfate activation of the AhR-NF-$\kappa$B pathway promotes interleukin-6 secretion and the subsequent osteogenic differentiation of human valvular interstitial cells from the aortic valve

Candellier, et al.

Journal of Molecular and Cellular Cardiology, 179, 18-29 (2023)

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Global Trade Item Number

SKU	GTIN
I3875-250MG	04061833856413
I3875-1G	04061833856406