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M49887

1-Methylhydantoin

Name: 1-Methylhydantoin
Brand: ALDRICH

97%

Synonym(s):

1-Methylimidazolidine-2,4-dione, Dioxy-creatinine, NSC 80560

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About This Item

Empirical Formula (Hill Notation):

C₄H₆N₂O₂

CAS Number:

616-04-6

Molecular Weight:

114.10

NACRES:

NA.22

PubChem Substance ID:

24896963

UNSPSC Code:

12352100

EC Number:

210-460-6

MDL number:

MFCD00003187

Assay:

97%

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Quality Level

200

assay

97%

mp

156-157 °C (lit.)

SMILES string

CN1CC(=O)NC1=O

InChI

1S/C4H6N2O2/c1-6-2-3(7)5-4(6)8/h2H2,1H3,(H,5,7,8)

InChI key

RHYBFKMFHLPQPH-UHFFFAOYSA-N

Related Categories

Heterocyclic Building Blocks

Application

Reactant for organocatalytic tandem three component reactions of aldehyde, alkyl vinyl ketone, and amide

Reactant for synthesis of:

Selective angiotensin II AT2 receptor agonists with reduced CYP 450 inhibition
Allosteric glucokinase activators
Hydantoin derivatives with antiproliferative activity
Thiohydantoins
P2X7 receptor antagonists

Storage Class

11 - Combustible Solids

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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[1-Methylhydantoin, an unexpected metabolite of the intelligence-affecting substance dupracetam (author's transl)].

H D Dell et al.

Archiv der Pharmazie, 314(8), 697-702 (1981-08-01)

1-Methylhydantoin cytotoxicity on renal proximal tubular cells in vitro.

Bo Yang et al.

Renal failure, 29(8), 1025-1029 (2007-12-11)

1-Methylhydantoin is produced by bacterial creatinine deaminase in the intestinal tract of uremic patients and retaken up into the body. The present study was designed to explore the toxic effect of 1-methylhydantoin on renal proximal tubular cells in vitro. HK-2

Biomolecular modules for creatinine determination.

A Warsinke et al.

Annals of the New York Academy of Sciences, 799, 541-544 (1996-10-12)

An enzymic creatinine assay and a direct ammonia assay in coated thin films.

M W Sundberg et al.

Clinical chemistry, 29(4), 645-649 (1983-04-01)

We developed a thin-film enzymic assay for creatinine that makes use of creatinine iminohydrolase (EC 3.5.4.21) to convert creatinine to N-methylhydantoin and ammonia. The ammonia diffuses through a semipermeable layer and is quantitated by reaction with bromphenol blue. A paired

Amidohydrolysis of N-methylhydantoin coupled with ATP hydrolysis.

J M Kim et al.

Biochemical and biophysical research communications, 142(3), 1006-1012 (1987-02-13)

A new enzyme, N-methylhydantoin amidohydrolase, was highly purified from Pseudomonas putida 77: it catalyzes the hydrolysis of N-methylhydantoin to N-carbamoylsarcosine with the concomitant stoichiometric cleavage of ATP to ADP and orthophosphate. The enzyme absolutely requires ATP, MG2+ and K+ for

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Global Trade Item Number

SKU	GTIN
M49887-25G	04061833327647

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