P12804
1,10-Phenanthroline monohydrate
≥99%
Synonym(s):
o-Phenanthroline monohydrate
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About This Item
Empirical Formula (Hill Notation):
C12H8N2 · H2O
CAS Number:
Molecular Weight:
198.22
EC Number:
200-629-2
UNSPSC Code:
12352103
MDL number:
Beilstein/REAXYS Number:
4008096
assay
≥99%
mp
100-104 °C (lit.)
SMILES string
O.c1cnc2c(c1)ccc3cccnc23
InChI
1S/C12H8N2.H2O/c1-3-9-5-6-10-4-2-8-14-12(10)11(9)13-7-1;/h1-8H;1H2
InChI key
PPQJCISYYXZCAE-UHFFFAOYSA-N
Application
When complexed with copper, it possesses nuclease activity that has been used to study DNA-protein interactions.
Biochem/physiol Actions
Metalloprotease inhibitor; chelates iron, zinc and other divalent metals. Effective concentration 1-10 mM.
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signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 3 Oral - Aquatic Acute 1 - Aquatic Chronic 1
Storage Class
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges
Regulatory Information
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Jing Yuan et al.
Nature chemical biology, 5(10), 765-771 (2009-09-08)
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Phedias Diamandis et al.
Nature chemical biology, 3(5), 268-273 (2007-04-10)
The identification of self-renewing and multipotent neural stem cells (NSCs) in the mammalian brain holds promise for the treatment of neurological diseases and has yielded new insight into brain cancer. However, the complete repertoire of signaling pathways that governs the