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Q0750

Quinidine hydrochloride monohydrate

technical grade

Synonym(s):

6′-Methoxycinchonan-9-ol hydrochloride monohydrate

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About This Item

Empirical Formula (Hill Notation):
C20H24N2O2 · HCl · H2O
CAS Number:
6151-40-2
Molecular Weight:
378.89
NACRES:
NA.22
PubChem Substance ID:
57654579
UNSPSC Code:
12352100
EC Number:
205-001-1
MDL number:
MFCD00198101
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grade

technical grade

Quality Level

200

impurities

≤20% Dihydroquinidine (according to USP specifications., actual content given on label)

SMILES string

O.Cl.[H][C@@]1(C[C@@H]2CC[N@H]1C[C@@H]2C=C)[C@@H](O)c3ccnc4ccc(OC)cc34

InChI

1S/C20H24N2O2.ClH.H2O/c1-3-13-12-22-9-7-14(13)10-19(22)20(23)16-6-8-21-18-5-4-15(24-2)11-17(16)18;;/h3-6,8,11,13-14,19-20,23H,1,7,9-10,12H2,2H3;1H;1H2/t13-,14-,19+,20-;;/m0../s1

InChI key

SGVZDMWHXVXUBY-KAIFKDDSSA-N

Gene Information

human ... SCN10A(6336), SCN11A(11280), SCN1A(6323), SCN2A(6326), SCN3A(6328), SCN4A(6329), SCN5A(6331), SCN7A(6332), SCN8A(6334), SCN9A(6335)

Application

Studied for pharmacological activity causing energy shifts from mitochondrial respiration to glycolysis

Biochem/physiol Actions

Class IA antiarrhythmic; potassium channel blocker.

pictograms

Exclamation mark
GHS07

signalword

Warning

Hazard Classifications

Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral

Storage Class

11 - Combustible Solids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
0000534171
0000534170
0000534171
0000534170
0000470020

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Miki Fukao et al.
European journal of drug metabolism and pharmacokinetics, 41(6), 819-824 (2015-12-03)
We have recently found an H We investigated the uptake and efflux of quinidine in MDCK cells. The uptake of 100 µM quinidine into MDCK cells was decreased by acidification of extracellular pH or alkalization of intracellular pH. In addition, the
Keisuke Oda et al.
The Journal of pharmacy and pharmacology, 69(12), 1736-1744 (2017-10-06)
Possible interaction of green tea beverage (GT) containing cyclodextrins and high concentration catechins, a drinking water, with P-glycoprotein (P-gp) substrates was examined in vitro and in vivo. Effects of GT on the uptake of rhodamine 123 by LLC-GA5-COL150 cells and intestinal efflux
Faisal E Al Jofi et al.
Cytotherapy, 20(5), 650-659 (2018-03-21)
Compelling evidence indicates that metformin, a low-cost and safe orally administered biguanide prescribed to millions of type 2 diabetics worldwide, induces the osteoblastic differentiation of mesenchymal stromal cells (MSCs) through the 5' adenosine monophosphate (AMP)-activated protein kinase (AMPK) pathway. As
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Global Trade Item Number

SKUGTIN
Q0750-5G04061836687670
Q0750-10G04061836687663