S550
Salicyloyl hydrazide
98%
Synonym(s):
Salicyl hydrazide, Salicylhydrazide
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About This Item
Linear Formula:
2-(HO)C6H4CONHNH2
CAS Number:
Molecular Weight:
152.15
UNSPSC Code:
12352100
PubChem Substance ID:
EC Number:
213-311-3
MDL number:
assay
98%
mp
147-150 °C (lit.)
SMILES string
NNC(=O)c1ccccc1O
InChI
1S/C7H8N2O2/c8-9-7(11)5-3-1-2-4-6(5)10/h1-4,10H,8H2,(H,9,11)
InChI key
XSXYESVZDBAKKT-UHFFFAOYSA-N
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Laith Q Al-Mawsawi et al.
Bioorganic & medicinal chemistry letters, 17(23), 6472-6475 (2007-10-24)
The previously discovered salicylhydrazide class of compounds displayed potent HIV-1 integrase (IN) inhibitory activity. The development of this class of compounds as antiretroviral agents was halted due to cytotoxicity in the nanomolar to sub-micromolar range. We identified a novel class
Xuefei Cao et al.
Current cancer drug targets, 9(2), 189-201 (2009-03-12)
Previously, we described a series of salicylhydrazide compounds with potent anti-cancer activities against a panel of human cancer cell lines derived from different origins. Preclinical evaluation showing efficacy both in vitro and in vivo in human cancer models indicated that
S A Thompson et al.
British journal of pharmacology, 142(1), 97-106 (2004-04-22)
1. A high-throughput assay utilizing the voltage/ion probe reader (VIPR) technology identified salicylidene salicylhydrazide (SCS) as being a potent selective inhibitor of alpha2beta1gamma1 GABA(A) receptors with a maximum inhibition of 56+/-5% and an IC(50) of 32 (23, 45) nm. 2.
Paul S Francis
Luminescence : the journal of biological and chemical luminescence, 19(4), 205-208 (2004-08-03)
The chemiluminescence accompanying the oxidation of salicylic hydrazide (2-hydroxybenzoic acid hydrazide) with hypochlorite, hypobromite, N-chlorosuccinimide, N-bromosuccinimide or hydrogen peroxide with cobalt(II) matched the photoluminescence emission of salicylic acid. In a related reaction, the oxidation of a mixture of isoniazid and
Muhib Ahmed et al.
Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine, 32(4), 671-682 (2019-06-24)
Hydrazide ligand, (Z)-N'-(6-oxo-1,10-phenanthrolin-5(6H)-ylidene)isonicotinohydrazide, 1 forms from a 1:1 Schiff base condensation reaction between isoniazid (INH) and 1,10-phenanthroline-5,6-dione (phendione). Ag+ and Mn2+ complexes with 1:2 metal:ligand stoichiometry are prepared: [Ag(1)2]NO3, [Ag(1)2]BF4 and [Mn(1)2](NO3)2. Polymeric {[Ag(1)(NO3)]}n has 1:1 stoichiometry and forms upon
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