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H8378

D-α-Hydroxyglutaric acid disodium salt

≥95% (GC), cell analysisfor peptide synthesis

Synonym(s):

(R)-2-Hydroxypentanedioic acid disodium salt, Disodium (R)-2-hydroxyglutarate

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About This Item

Linear Formula:
C5H6O5Na2
CAS Number:
103404-90-6
Molecular Weight:
192.08
NACRES:
NA.22
PubChem Substance ID:
57654274
UNSPSC Code:
12352106
MDL number:
MFCD00069573
Beilstein/REAXYS Number:
5318041
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Product Name

D-α-Hydroxyglutaric acid disodium salt, ≥95% (GC)

Quality Level

200

assay

≥95% (GC)

form

powder

color

white to off-white

application(s)

cell analysis
peptide synthesis

storage temp.

−20°C

SMILES string

[Na].O[C@H](CCC(O)=O)C(O)=O

InChI

1S/C5H8O5.2Na/c6-3(5(9)10)1-2-4(7)8;;/h3,6H,1-2H2,(H,7,8)(H,9,10);;/q;2*+1/p-2/t3-;;/m1../s1

InChI key

DZHFTEDSQFPDPP-HWYNEVGZSA-L

Application

D-α-Hydroxyglutaric acid disodium salt can be used as a reagent in peptide synthesis.

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Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Certificates of Analysis (COA)

Lot/Batch Number
0000450134
0000450132
0000450132
0000450134
0000445996

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Protocols

Chiral LC-MS/MS of D- and L-2-Hydroxyglutaric Acid Biomarkers

We describe here a rapid and sensitive method to separate and measure D-2-OHG and L-2-OHG enantiomers using high-resolution mass spectrometry (HRMS) detection.

Shan Jin et al.
Nature communications, 14(1), 6638-6638 (2023-10-21)
Mammalian lactate dehydrogenase D (LDHD) catalyzes the oxidation of D-lactate to pyruvate. LDHD mutations identified in patients with D-lactic acidosis lead to deficient LDHD activity. Here, we perform a systematic biochemical study of mouse LDHD (mLDHD) and determine the crystal
The tumor suppressor prostate apoptosis response-4 (Par-4) is regulated by mutant IDH1 and kills glioma stem cells.
Liu Y, Gilbert MR, Kyprianou N, et al.
Acta Neuropathologica, 128(5), 723-732 (2014)
M Hans et al.
European journal of biochemistry, 265(1), 404-414 (1999-09-22)
Component D (HgdAB) of 2-hydroxyglutaryl-CoA dehydratase from Clostridium symbiosum was purified to homogeneity. It is able to use component A from Acidaminococcus fermentans (HgdC) to initiate catalysis together with ATP, Mg2+ and a strong reducing agent such as Ti(III)citrate. Component
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Global Trade Item Number

SKUGTIN
H8378-100MG04061833809198
H8378-250MG04061833810651