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About This Item
Empirical Formula (Hill Notation):
C19H28O2
CAS Number:
Molecular Weight:
288.42
MDL number:
UNSPSC Code:
12352211
NACRES:
NA.25
description
Dehydroepiandrosterone
assay
>99% (TLC)
form
powder
packaging
pkg of 1 × 1 g (700087P-1g)
manufacturer/tradename
Avanti Research™ - A Croda Brand
shipped in
dry ice
storage temp.
−20°C
SMILES string
O[C@H]1CC[C@@]2([C@@H]3[C@H]([C@H]4[C@](CC3)(C(=O)CC4)C)CC=C2C1)C
InChI
1S/C19H28O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h3,13-16,20H,4-11H2,1-2H3/t13-,14-,15-,16-,18-,19-/m0/s1
InChI key
FMGSKLZLMKYGDP-USOAJAOKSA-N
General description
25-hydroxy-cholesterol is a metabolite of cholesterol. It is produced by macrophages.
Dehydroepiandrosterone (DHEA) is a carbon (C)-19 neuroactive steroid. It is synthesized by the adrenal gland in humans and mammals.
DHEA (dehydroepiandrosterone) is an endogenous steroid hormone secreted by the adrenal gland. DHEA serves as precursor to male and female sex hormones (androgens and estrogens).
Biochem/physiol Actions
25-hydroxy-cholesterol represses the production of IgA by B cells, manages the migration of activated B cells in the germinal follicle. It regulates the differentiation of monocytes into macrophages. 25-hydroxy-cholesterol plays a critical role in lipid biosynthesis and immunity. It inhibits sterol regulatory element-binding protein (SREBP) proteolytic processing and modulates cholesterol metabolism.
Dehydroepiandrosterone (DHEA) regulates neural functions, such as neurogenesis, neuroprotection, neuronal growth and differentiation. It is used to treat multiple sclerosis. DHEA acts as a precursor of sex steroid biosynthesis.
Packaging
20 mL Clear Glass Screw Cap Vial (700087P-1g)
Legal Information
Avanti Research is a trademark of Avanti Polar Lipids, LLC
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signalword
Warning
hcodes
Hazard Classifications
Repr. 2
Storage Class
11 - Combustible Solids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
监管及禁止进口产品
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25-Hydroxycholesterol activates the integrated stress response to reprogram transcription and translation in macrophages
Shibata N, et al.
The Journal of biological chemistry, 288(50), 35812-35823 (2013)
25-Hydroxycholesterol: a new life in immunology
McDonald JG and Russell DW
Journal of Leukocyte Biology, 88(6), 1071-1072 (2010)
Sex Hormones in Neurodegenerative Processes and Diseases (2018)
Global Trade Item Number
| SKU | GTIN |
|---|---|
| 700087P-1G | 04061835383634 |