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About This Item
NACRES:
NA.84
Species reactivity:
human
Technique(s):
single molecule counting: suitable
Compatibility:
for use with FemtoQuest™instruments
General description
The IL-17 cytokine family is vital for protective immunity and inflammatory pathology during infection and autoimmunity. Dysregulated IL-17 responses can lead to immunopathology in various disorders, making the IL-17 pathway a key drug target in autoimmune and chronic inflammatory disorders. Understanding the multifunctional properties of IL-17 is crucial for future studies aiming to regulate its expression and function, particularly in the context of autoimmune diseases and tumors.
Application
InflammatoryDisease / Immune Response / Autoimmune Disease
Features and Benefits
- Analyze 2 analytes in a single sample, saving sample volume and hands-on time
- Lot matched components for consistent performance
- Femtogram/mL sensitivity
- Follows a traditional assay workflow, similar to and ELISA
- Receive detailed assay characteristics in the kit Certificate of Analysis
- Quality Control provided, with instructions for preparation of 2-3 QCs
Packaging
96well assay
Analysis Note
IL-17A:
- Sensitivity: LLOQ 20 fg/mL* (FemtoQuest™ Instrument)
- Standard Curve Range: 20-60,000 fg/mL
- Intra-assay CV: <15%
- Inter-assay CV: <20%
- Linearity: Plasma 82-186%, Serum 61-106%
- Recovery: Plasma 94-121%, Serum 88-112%
- Sensitivity: LLOQ 90 fg/mL* (FemtoQuest™ Instrument)
- Standard Curve Range: 90-300,000 fg/mL
- Intra-assay CV: <15%
- Inter-assay CV: <20%
- Linearity: Plasma 31-108%, Serum 77-117%
- Recovery: Plasma 79-107%, Serum 79-101%
Other Notes
AlthoughIL-17A was detectable in non-human primate, mouse, rat, canine, and felinesamples, the assay has not been verified for these species.
AlthoughIL-17F was detectable in non-human primate, rat, and feline samples, the assayhas not been verified for these species.
AlthoughIL-17F was detectable in non-human primate, rat, and feline samples, the assayhas not been verified for these species.
Legal Information
FEMTOQUEST is a trademark of Merck KGaA, Darmstadt, Germany
SMC is a registered trademark of Singulex
Disclaimer
Ourproducts are intended for research use only and are not to be used for anyother purpose, which includes but is not limited to, unauthorized commercialuses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any typeof consumption or application to humans or animals.
signalword
Danger
Hazard Classifications
Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Aquatic Chronic 3 - ED ENV 1 - Eye Irrit. 2 - Repr. 1B - STOT RE 2 Inhalation
target_organs
Respiratory Tract
Storage Class
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
wgk
WGK 3
Regulatory Information
新产品
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Certificates of Analysis (COA)
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Global Trade Item Number
| SKU | GTIN |
|---|---|
| 03-0214-2P | 04065272034029 |