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About This Item
NACRES:
NA.46
Species reactivity:
human
Technique(s):
single molecule counting: suitable
Compatibility:
for use with FemtoQuest™instruments
General description
IL-23 and IL-22 play significant roles in the progression of various autoimmune and inflammatory diseases through their effects on immune responses. IL-23 primarily drives the inflammatory response through its role in promoting Th17 cells and their cytokines, while IL-22 contributes to inflammation and tissue damage in various autoimmune diseases. Both are involved in the pathogenesis of chronic inflammatory conditions, such as inflammatory bowel disease (ulcerative colitis and Crohn’s disease), rheumatoid arthritis, psoriasis, and multiple sclerosis, making them important targets for therapeutic interventions.
Application
InflammatoryDisease / Immune Response / Autoimmune Disease
Features and Benefits
- Analyze 2 analytes in a single sample, saving sample volume and hands-on time
- Lot matched components for consistent performance
- Femtogram/mL sensitivity
- Follows a traditional assay workflow, similar to and ELISA
- Receive detailed assay characteristics in the kit Certificate of Analysis
- Quality Control provided, with instructions for preparation of 2-3 QCs
Packaging
96 well assay
Analysis Note
IL-22:
- Sensitivity: LLOQ 90 fg/mL* (FemtoQuest™ Instrument)
- Standard Curve Range: 90-200,000 fg/mL
- Intra-assay CV: <15%
- Inter-assay CV: <20%
- Linearity: Plasma 88-115%, Serum 95-124%
- Recovery: Plasma 101-116%, Serum 80-95%
- Sensitivity: LLOQ 40 fg/mL* (FemtoQuest™ Instrument)
- Standard Curve Range: 40-100,000 fg/mL
- Intra-assay CV: <15%
- Inter-assay CV: <20%
- Linearity: Plasma 72-101%, Serum 78-101%
- Recovery: Plasma 86-122%, Serum 99-111%
Other Notes
AlthoughIL-23 was detectable in non-human primate, rat, canine, rabbit, and guinea pigsamples, the assay has not been verified for these species.
AlthoughIL-22 was detectable in non-human primate, mouse, rat, canine, feline, andequine samples, the assay has not been verified for these species.
AlthoughIL-22 was detectable in non-human primate, mouse, rat, canine, feline, andequine samples, the assay has not been verified for these species.
Legal Information
FEMTOQUEST is a trademark of Merck KGaA, Darmstadt, Germany
SMC is a registered trademark of Singulex
Disclaimer
Ourproducts are intended for research use only and are not to be used for anyother purpose, which includes but is not limited to, unauthorized commercialuses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any typeof consumption or application to humans or animals.
signalword
Danger
Hazard Classifications
Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Aquatic Chronic 3 - ED ENV 1 - Eye Irrit. 2 - Repr. 1B - STOT RE 2 Inhalation
target_organs
Respiratory Tract
Storage Class
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
wgk
WGK 3
Regulatory Information
新产品
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Certificates of Analysis (COA)
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Global Trade Item Number
| SKU | GTIN |
|---|---|
| 03-0215-2P | 04065272039321 |