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Merck
CN

04-151

Anti-IFNAR-1 Antibody, clone MARI-5A3

clone MARI-5A3, from mouse

Synonym(s):

interferon (alpha, beta and omega) receptor 1, beta-type antiviral protein, alpha-type antiviral protein, Type I interferon receptor 1, Cytokine receptor family 2 member 1, interferon-beta receptor 1, Cytokine receptor class-II member 1, IFN-alpha-REC, i

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41
eCl@ss:
32160702
Conjugate:
unconjugated
Clone:
MARI-5A3, monoclonal
Application:
flow cytometry
immunoprecipitation (IP)
neutralization
western blot
Species reactivity:
mouse
Citations:
1
Technique(s):
flow cytometry: suitable
immunoprecipitation (IP): suitable
neutralization: suitable
western blot: suitable
Uniprot accession no.:
P33896

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Product Name

Anti-IFNAR-1 Antibody, clone MARI-5A3, clone MARI-5A3, from mouse

biological source

mouse

conjugate

unconjugated

antibody form

purified antibody

antibody product type

primary antibodies

clone

MARI-5A3, monoclonal

species reactivity

mouse

technique(s)

flow cytometry: suitable
immunoprecipitation (IP): suitable
neutralization: suitable
western blot: suitable

isotype

IgG1κ

NCBI accession no.

NP_034638

UniProt accession no.

P33896

shipped in

wet ice

target post-translational modification

unmodified

Quality Level

100

Gene Information

mouse ... Ifnar1(15975)

Related Categories

Analysis Note

Evaluated by Flow Cytometry in BALB/c splenocytes.

Flow Cytometry Analysis: 5 µg of this antibody detected IFNAR-1 in BALB/c splenocytes.

Application

Anti-IFNAR-1 Antibody, clone MARI-5A3 is an antibody against IFNAR-1 for use in FC, IP, WB, NEUT.
Western Blot Analysis: A previous lot was used by an independent laboratory in WB. (Sheehan, K., et al. (2006). Journal of Interferon & Cytokine Research. 26:804-819.)

Immunoprecipitation Analysis: A previous lot was used by an independent laboratory in IP. (Sheehan, K., et al. (2006). Journal of Interferon & Cytokine Research. 26:804-819.)

Flow Cytometry Analysis: A previous lot was used by an independent laboratory in FC. (Sheehan, K., et al. (2006). Journal of Interferon & Cytokine Research. 26:804-819.)

Neutralizing Assay: A previous lot was used by an independent laboratory in neutralization studies. (Sheehan, K., et al. (2006). Journal of Interferon & Cytokine Research. 26:804-819.)

Biochem/physiol Actions

This antibody recognizes the extracellular domain of IFNAR-1.

General description

63 kDa calculated
Interferon alpha/beta receptor 1 (IFNAR-1) is a single-pass type I membrane protein containing three fibronectin type-III domains and is a member of the type II cytokine receptor family. IFNAR-1 serves as an interferon receptor specific to interferons alpha and beta, a family of type I interferons critical to the promotion and the linking of adaptive and innate immune response. Type I interferons all bind to a heterodimeric receptor composed of two subunits, IFNAR-1 and IFNAR-2. The binding of the type I IFNs initializes tyrosine phosphorylation for several proteins such as; IFNR alpha/beta subunits, JAKs, STAT, and TYK2 proteins.

Immunogen

Recombinant protein corresponding to the extracellular domain of mouse IFNAR-1.

Other Notes

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Physical form

Format: Purified

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Storage Class

12 - Non Combustible Liquids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Louise Malle et al.
Immunity, 55(11), 2074-2084 (2022-10-16)
Down syndrome (DS) is typically caused by triplication of chromosome 21. Phenotypically, DS presents with developmental, neurocognitive, and immune features. Epidemiologically, individuals with DS have less frequent viral infection, but when present, these infections lead to more severe disease. The

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