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1.06323

Sodium hydrogen carbonate

Name: Sodium hydrogen carbonate
Brand: MM

EMPROVE^® ESSENTIAL, Ph. Eur., BP, ChP, JP, USP, FCC, E 500

Synonym(s):

Sodium bicarbonate

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About This Item

Linear Formula:

NaHCO₃

CAS Number:

144-55-8

Molecular Weight:

84.01

UNSPSC Code:

12352302

EC Index Number:

205-633-8

E Number:

E500

MDL number:

MFCD00003528

Beilstein/REAXYS Number:

4153970

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Properties

Quality Level

500

agency

BP, ChP, JP, Ph. Eur., USP

reg. compliance

FCC

product line

EMPROVE^® ESSENTIAL

form

solid

pH

8.6 (20 °C, 50 g/L in H₂O)

pKa (25 °C)

(1) 6.37, (2) 10.25 (carbonic acid)

mp

270 °C (decomposition)

solubility

96 g/L

density

2.22 g/cm³ at 20 °C, 2.16 g/mL at 25 °C (lit.)

application(s)

liquid formulation
ophthalmics
pharmaceutical
solid formulation

storage temp.

2-30°C

SMILES string

[Na+].OC([O-])=O

InChI

1S/CH2O3.Na/c2-1(3)4;/h(H2,2,3,4);/q;+1/p-1

InChI key

UIIMBOGNXHQVGW-UHFFFAOYSA-M

Description

General description

Finding the right excipient that matches your needs as well as regulatory demands can be a complicated challenge in formulation. With our application know-how and regulatory expertise, we support you in every step of development, scale-up, and production.
As part of our Emprove^® Program, our raw materials are offered with extensive documentation facilitating compliance of your pharma and biopharma product, full supply chain transparency and risk mitigation. Our SAFC^® portfolio of high-quality products for biopharmaceutical and pharmaceutical formulation and production withstands strict quality control procedures and is produced according to applicable cGMP guidelines.

Application

Sodium hydrogen carbonate is a commonly used ingredient in both food and pharmaceutics. In pharmaceutical applications, sodium hydrogen carbonate is used as pH adjuster, or a source of carbon dioxide in oral formulations such as effervescent tablets or granules.

Legal Information

Emprove is a registered trademark of Merck KGaA, Darmstadt, Germany

SAFC is a registered trademark of Merck KGaA, Darmstadt, Germany

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Storage Class

11 - Combustible Solids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c