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1.37148

Triethanolamine

Name: Triethanolamine
Brand: MM

EMPROVE^® EXPERT, Ph. Eur., JPE, NF

Synonym(s):

2,2′,2′′-Nitrilotriethanol, Tris(2-hydroxyethyl)amine

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About This Item

Linear Formula:

(HOCH₂CH₂)₃N

CAS Number:

102-71-6

Molecular Weight:

149.19

UNSPSC Code:

12352104

Beilstein/REAXYS Number:

1699263

MDL number:

MFCD00002855

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Properties

Quality Level

500

agency

JPE, NF, Ph. Eur.

vapor density

5.14 (vs air)

vapor pressure

0.01 mmHg ( 20 °C)

product line

EMPROVE^® EXPERT

form

liquid

autoignition temp.

600 °F

expl. lim.

8.5 %

technique(s)

API processing | cocrystal formation: suitable

refractive index

n20/D 1.485 (lit.)

useful pH range

7.3-8.3

pKa (25 °C)

7.8

bp

190-193 °C/5 mmHg (lit.)

mp

17.9-21 °C (lit.)

density

1.124 g/mL at 25 °C (lit.)

application(s)

liquid formulation
pharmaceutical
semi-solid formulation

storage temp.

2-25°C

SMILES string

OCCN(CCO)CCO

InChI

1S/C6H15NO3/c8-4-1-7(2-5-9)3-6-10/h8-10H,1-6H2

InChI key

GSEJCLTVZPLZKY-UHFFFAOYSA-N

Description

General description

Finding the right excipient that matches your needs as well as regulatory demands can be a complicated challenge. With our application know-how and regulatory expertise, we support you in every step of development, scale-up, and production.
As part of our Emprove^® Program, our raw materials are offered with extensive documentation facilitating compliance of your pharma and biopharma product, full supply chain transparency and risk mitigation. Our SAFC^® portfolio of high-quality products for biopharmaceutical and pharmaceutical formulation and production withstands strict quality control procedures and is produced according to applicable cGMP guidelines.

Application

Triethanolamine (Trolamine) is a tertiary amine that acts as a basic buffer component, typically used as a final formulation buffer for small molecules pharmaceuticals. It may also be used as a process buffer in cell lysis and biomolecule downstream chromatography.
As a multi-compendial product, Triethanolamine (Trolamine) Emprove^® Expert meets the N-nitrosodiethanolamine limits required by Ph Eur. Also, low microbial and endotoxin limits facilitate the use of this product in high-risk applications.

Legal Information

Emprove is a registered trademark of Merck KGaA, Darmstadt, Germany

SAFC is a registered trademark of Merck KGaA, Darmstadt, Germany

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Storage Class

10 - Combustible liquids

wgk

WGK 1

flash_point_f

354.2 °F - closed cup

flash_point_c

179 °C - closed cup

Regulatory Information

监管及禁止进口产品

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Articles

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Instead of addressing API solubility during formulation, tackle it early during development. Read about the various methods for API processing.

Global Trade Item Number

SKU	GTIN
1371486025	04054839022531