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1.02144

Calcium hydrogen phosphate

Name: Calcium hydrogen phosphate
Brand: MM

anhydrous, fine powder, EMPROVE^® ESSENTIAL, Ph. Eur., BP, ChP, USP, FCC, E 341(ii)

Synonym(s):

Calcium hydrogen phosphate, Calcium orthophosphate, Calcium phosphate dibasic

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About This Item

Empirical Formula (Hill Notation):

HCaO₄P

CAS Number:

7757-93-9

Molecular Weight:

136.06

UNSPSC Code:

12352302

E Number:

E341 (ii)

EC Index Number:

231-826-1

MDL number:

MFCD00010909

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Properties

Quality Level

500

agency

BP, ChP, Ph. Eur., USP

reg. compliance

FCC

product line

EMPROVE^® ESSENTIAL

form

fine powder

potency

10000 mg/kg LD₅₀, oral (Rat), >7940 mg/kg LD₅₀, skin (Rabbit)

particle size

(see specification)

pH

7 (20 °C, 10 g/L in H₂O, suspension)

mp

370 °C (decomposition)

density

2.89 g/cm³ at 20 °C

application(s)

pharmaceutical
semi-solid formulation
solid formulation

storage temp.

2-30°C

SMILES string

[Ca+2].[P](=O)([O-])([O-])[O-].[H+]

InChI

1S/Ca.H3O4P/c;1-5(2,3)4/h;(H3,1,2,3,4)/q+2;/p-2

InChI key

FUFJGUQYACFECW-UHFFFAOYSA-L

Description

General description

To address challenges of solid formulation manufacturing, we have developed a comprehensive product portfolio to meet with your solid dosage needs in mind. Although solid dose formulations are one of the the most established dosage forms in the pharmaceutical market, the complexity of manufacturing final drug products is becoming more and more challenging. API stability, release kinetics and bioavailability limitations, such as low API solubility, are just a few of many critical obstacles on the way to the market.
As part of our Emprove^® Program, our raw materials are offered with extensive documentation facilitating compliance of your pharma and biopharma product, full supply chain transparency and risk mitigation. Our SAFC^® portfolio of high-quality products for biopharmaceutical and pharmaceutical formulation and production withstands strict quality control procedures and is produced according to applicable cGMP guidelines.

Application

Calcium hydrogen phosphate is a commonly used ingredient in both food and pharmaceutics. In pharmaceutical applications, calcium hydrogen phosphate is primarily used as a filler/binder.

Legal Information

Emprove is a registered trademark of Merck KGaA, Darmstadt, Germany

SAFC is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class

13 - Non Combustible Solids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c