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104662

Cellvento® ModiFeed Sial+ COMP

Chemically defined, CHO fed-batch feed to maximize sialylation, Emprove® CCM

greener alternative

Greener Alternative

Synonym(s):

CD Animal-Free Fed-Batch Supplement, Cellvento® ModiFeed Sial+, High Sialylation CHO Feed, Sialylation Modulation Feed, Sialylation-Increasing CHO Feed, Terminal Sialylation Feed

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About This Item

UNSPSC Code:
41106213
Technical Service
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Quality Segment

biological source

non-animal source

description

shipped with cooling packs

product line

Cellvento®

form

dry powder

greener alternative product characteristics

Design for Energy Efficiency
Learn more about the Principles of Green Chemistry.

sustainability

Greener Alternative Product

technique(s)

cell culture | mammalian: suitable

application(s)

pharma/biopharma processes

components

glucose: no

greener alternative category

storage temp.

2-8°C

General description

Cellvento® ModiFeed Sial+ COMP is a chemically defined, non-animal origin, complete cell culture feed EMPROVE®CCM supplied as a compacted dry powder for simplified handling and rapid hydration. It is Part of the ModiFeed glycosylation-modulating feed platform, this highly concentrated, single-part, pH-neutral fed-batch feed is engineered to maximize sialylation on the therapeutic protein of interest a critical quality attribute (CQA) directly influencing the biological activity, solubility, serum half-life, and safety of therapeutic glycoproteins.On combination with Cellvento® ModiFeed Prime it allows tunable Sialylation.

Cellvento® ModiFeed Sial+ COMPsupported by the Emprove® Program and designated DfS, making it suitable for scalable, quality-focused biologics manufacturing workflows.

We are committed to bringing you Greener Alternative Products, which belongs to one of the four categories of greener alternatives. This product is a Design for Sustainability (DfS) developed product. Click here to view its DfS scorecard.

Application

Cellvento® ModiFeed Sial+ COMP is used for:
  • Monoclonal antibody (mAb) development and commercial biopharmaceutical manufacturing in CHO cell-based expression systems
  • Biosimilar development requiring precise, titratable sialylation profile control to match originator glycan fingerprints
  • Upstream fed-batch and intensified fed-batch bioprocessing where maximized terminal sialylation is a defined CQA
  • Next-generation therapeutic glycoprotein production targeting enhanced anti-inflammatory activity, stability, and efficacy
  • Mixed feed glycosylation tuning mcombinable with Cellvento® ModiFeed Prime COMP to dial in a precise target sialylation level across a titratable spectrum
  • Compatible with Cellvento® 4CHO COMP and EX-CELL® Advanced CHO production media for a fully integrated, chemically defined upstream CHO bioprocess platform

Features and Benefits

  • Complete feed engineered to maximize sialylation
  • One-part, pH-neutral complete feed for simplified fed-batch process
  • Maximizes terminal galactosylation without compromising titer
  • Highly concentrated to reduce feed volume added to bioreactor
  • Compacted powder for convenient handling and easy hydration
  • Ambient-stable hydrated solution up to 30 days
  • Chemically defined, no animal-origin components
  • No glucose enabling precise glucose control
  • Supported by EMPROVE® CCM Program

Preparation Note

Formulated to contain 155.8 grams of powder per liter of feed.

Legal Information

CELLVENTO is a registered trademark of Merck KGaA, Darmstadt, Germany
EX-CELL is a registered trademark of Merck KGaA, Darmstadt, Germany
Emprove is a registered trademark of Merck KGaA, Darmstadt, Germany


Storage Class

11 - Combustible Solids

wgk

WGK 3



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