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1.37028

Glycerol

Name: Glycerol
Brand: MM

anhydrous (vegetable), EMPROVE^® EXPERT, Ph. Eur., BP, JP, USP, ACS

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Synonym(s):

1,2,3-Propanetriol, Trihydroxylpropane, Protol, Glycerin, 1,2,3-Propanetriol, Glycerin

Linear Formula:

HOCH₂CH(OH)CH₂OH

CAS Number:

56-81-5

Molecular Weight:

92.09

Beilstein:

635685

MDL number:

MFCD00004722

EC Index Number:

200-289-5

grade

ACS reagent

Quality Level

500

Agency

BP
JP
Ph. Eur.
USP

vapor density

3.1 (vs air)

vapor pressure

<1 mmHg ( 20 °C)

product line

EMPROVE^® EXPERT

Assay

≤98.0-101.0% (calculated on anhydrous substance, alkalimetric)
≥99.5% (calculated on anhydrous substance, GC)

form

liquid

autoignition temp.

698 °F

expl. lim.

2.6-11.3 % (v/v)

greener alternative product characteristics

Safer Solvents and Auxiliaries
Use of Renewable Feedstocks
Learn more about the Principles of Green Chemistry.

technique(s)

electrophoresis: suitable

refractive index

n20/D 1.474 (lit.)

pH

5 (20 °C, 100 g/L in H₂O)

bp

182 °C/20 mmHg (lit.)

mp

20 °C (lit.)

transition temp

flash point 199 °C

density

1.25 g/mL (lit.)

application(s)

liquid formulation
ophthalmics
parenterals
pharma/biopharma processes
pharmaceutical

greener alternative category

Aligned,

storage temp.

2-30°C

SMILES string

OCC(O)CO

InChI

1S/C3H8O3/c4-1-3(6)2-5/h3-6H,1-2H2

InChI key

PEDCQBHIVMGVHV-UHFFFAOYSA-N

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Related Categories

Biopharmaceutical Formulation

Downstream Process & Formulation Chemicals

Excipients for Your Liquid Application

Greener Alternative Products

Injectables & Parenteral Formulations

General description

Finding the right excipient that matches your needs as well as regulatory demands can be a complicated challenge in formulation. With our application know-how and regulatory expertise, we support you in every step of development, scale-up, and production.
As part of our Emprove^® Program, our raw materials are offered with extensive documentation facilitating compliance of your pharma and biopharma product, full supply chain transparency and risk mitigation. Our SAFC^® portfolio of high-quality products for biopharmaceutical and pharmaceutical formulation and production withstands strict quality control procedures and is produced according to applicable cGMP guidelines.

We are committed to bringing you Greener Alternative Products, which adhere to one or more of The 12 Principles of Green Chemistry. This product is a bio-based glycerol and is aligned with the 5th principle of Green Chemistry "Safer Solvents and Auxiliaries" and 7th principle "Use of Renewable Feedstock". Click here for more details.

Application

Glycerol can be used in a wide variety of solid, semi-solid and liquid formulations, including ophthalmic, oral solid and oral liquid dosages, tablet coatings, creams and gels. It is applied for its humectant, emollient, solvent/cosolvent, viscosity increasing, and plasticizer properties.
Glycerol anhydrous (vegetable) Emprove^® Expert is low in endotoxins and bioburden, making it the right choice for your high-risk applications.

Glycerol is used both in sample preparation and gel formation for polyacrylamide gel electrophoresis. Glycerol (5-10%) increases the density of a sample so that the sample will layer at the bottom of a gel′s sample well. Glycerol is also used to aid in casting gradient gels and as a protein stabilizer and storage buffer component.

Legal Information

Emprove is a registered trademark of Merck KGaA, Darmstadt, Germany

SAFC is a registered trademark of Merck KGaA, Darmstadt, Germany

related product

Product No.

Description

Pricing

Storage Class Code

10 - Combustible liquids

WGK

WGK 1

Flash Point(F)

390.2 °F - Pensky-Martens closed cup

Flash Point(C)

199 °C - Pensky-Martens closed cup

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Articles

Strategies for the Development of Safe and Effective Pediatric Formulations

Medicine for children poses unique formulation challenges compared to adults. Consider developmental physiology and age specifics when designing pharmaceuticals. Quality issues can severely impact patient safety. Therefore, excipient quality, supplier selection, and supply chain security are crucial, particularly for pediatric formulations.