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SAFC

Tetrahydrofuran

EMPROVE® ESSENTIAL

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Synonym(s):
Tetrahydrofuran, Butylene oxide, Oxolane, Tetramethylene oxide
Empirical Formula (Hill Notation):
C4H8O
CAS Number:
109-99-9
Molecular Weight:
72.11
Beilstein:
102391
MDL number:
MFCD00005356

vapor density

2.5 (vs air)

Quality Level

500

vapor pressure

114 mmHg ( 15 °C)
143 mmHg ( 20 °C)

product line

EMPROVE® ESSENTIAL

Assay

≥99.8% (GC)

form

liquid

autoignition temp.

610 °F

expl. lim.

1.8-11.8 %

technique(s)

API processing | polymorph screening: suitable

refractive index

n20/D 1.407 (lit.)

pH

7-8 (20 °C, 200 g/L in H2O)

bp

65-67 °C (lit.)

mp

−108 °C (lit.)

density

0.889 g/mL at 25 °C (lit.)

application(s)

pharmaceutical

storage temp.

2-25°C

SMILES string

C1CCOC1

InChI

1S/C4H8O/c1-2-4-5-3-1/h1-4H2

InChI key

WYURNTSHIVDZCO-UHFFFAOYSA-N

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General description

We offer a range of high quality critical raw materials, solvents and reagents plus the documentation and expertise to meet stringent regulatory requirements. In addition to our comprehensive portfolio, we also offer custom manufacturing services to meet your exact needs. As part of our Emprove® Program, our raw materials are offered with extensive documentation facilitating compliance of your pharma and biopharma product, full supply chain transparency and risk mitigation. Our SAFC® portfolio of high-quality products for biopharmaceutical and pharmaceutical formulation and production withstands strict quality control procedures and is produced according to applicable cGMP guidelines.

Application

Tetrahydrofuran is a versatile organic solvent for API synthesis, as a pre-cursor to polymers and it is used for several extended applications during drug manufacturing. The performance of the processes increases with the usage of Tetrahydrofuran in certain API′s than other available solvents. Tetrahydrofuran Emprove® Essential is manufactured according to GMP guidelines and is suitable for pharmaceutical applications.

Linkage

Emprove Documentation

Legal Information

Emprove is a registered trademark of Merck KGaA, Darmstadt, Germany
SAFC is a registered trademark of Merck KGaA, Darmstadt, Germany

Signal Word

Danger

Hazard Classifications

Acute Tox. 4 Oral - Carc. 2 - Eye Irrit. 2 - Flam. Liq. 2

Supplementary Hazards

EUH019

Storage Class Code

3 - Flammable liquids

WGK

WGK 1

Flash Point(F)

-6.2 °F - closed cup

Flash Point(C)

-21.2 °C - closed cup

Regulatory Information

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