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149101-M

1-Aminocyclopropanecarboxylic acid

Name: 1-Aminocyclopropanecarboxylic acid
Brand: MM

≥98% (TLC), crystalline solid, NMDA agonist, Calbiochem

Synonym(s):

1-Aminocyclopropane-1-carboxylic Acid, ACPC

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About This Item

Empirical Formula (Hill Notation):

C₄H₇NO₂

CAS Number:

22059-21-8

Molecular Weight:

101.10

UNSPSC Code:

12352106

NACRES:

NA.77

MDL number:

MFCD00009944

Assay:

≥98% (TLC)

Form:

crystalline solid

Quality level:

100

Storage condition:

OK to freeze

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Properties

Product Name

1-Aminocyclopropane-1-carboxylic Acid, An agonist for the glycine modulatory site of the N-methyl-D-aspartate (NMDA) receptor complex.

Quality Level

100

description

RTECS - GZ1110000

assay

≥98% (TLC)

form

crystalline solid

manufacturer/tradename

Calbiochem^®

storage condition

OK to freeze

solubility

water: 40 mg/mL

storage temp.

10-30°C

SMILES string

[N+H3]C1(CC1)C(=O)[O-]

InChI

1S/C4H7NO2/c5-4(1-2-4)3(6)7/h1-2,5H2,(H,6,7)

InChI key

PAJPWUMXBYXFCZ-UHFFFAOYSA-N

Description

General description

A potent and selective ligand for the glycine modulatory site of the N-methyl-D-aspartate (NMDA) receptor complex. Blocks ³H-glycine binding to rat forebrain membranes (IC₅₀ = 38 nM).

An agonist for the glycine modulatory site of the N-methyl-D-aspartate (NMDA) receptor complex. Mimics the effects of glycine on the NMDA receptor ion channel and blocks ³H-glycine binding to rat forebrain membrane (IC₅₀ = 38 nM). Blocks NMDA-induced release of arachidonic acid (IC₅₀ = 131 µM) in cerebellar granule cells. Reduces NMDA-induced cell death in hippocampal neurons.

Biochem/physiol Actions

Primary Target
Glycine modulatory site of the N-methyl-D-aspartate (NMDA) receptor complex

Target IC₅₀: 38 nM in blocking 3H-glycine binding to rat forebrain membrane; 131 µM in blocking NMDA-induced release of arachidonic acid; 131 µM in cerebellar granule cells

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.

May require heating and sonication to achieve complete solubilization.

Other Notes

Viu, E., et al. 1998. J. Pharm. Exp. Ther.285, 527.
Zapata, A., et al. 1996. NeuroReport7, 397.
Kolesnikov, Y.A., et al. 1994. Life Sci. 55, 1393.
Rottmann, W.H., et al. 1991. J. Mol. Biol.222, 937.
Marvizon, J.C., et al. 1989. J. Neurochem.52, 992.
Nadler, V., et al. 1988. Eur. J. Pharmacol.157, 115.
Adams, D.O., and Yang, S.F. 1979. Proc. Natl. Acad. Sci. USA76, 170.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Irritant (B)

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Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c