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Bioactive Small Molecule Agonists

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Critical for researchers aiming to probe protein activity within cells, bioactive small molecule (BSM) agonists are chemical probes that mimic the natural ligands of receptors by binding them and activating their natural biological response. This can include stimulating target protein activity or initiating signaling cascades. As they enhance enzymatic activity, BSM agonists are crucial compounds for researchers investigating protein functions and protein-protein interactions, or as lead compounds during therapeutic development for cancer, cardiovascular disease, or neurological disorders.

Our collection of high quality bioactive small molecule agonists enhances your drug discovery applications, probe receptor functions, and investigate cellular signaling pathways.

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Small Molecule Agonists

Small molecule agonists have been used in pharmacological, cancer, and neuroscience research to investigate receptor signaling cascades and understand how protein receptors are involved in different disease states. Because BSM agonists active receptors, they can be used as lead compounds for drug discovery and development. Two examples of BSM agonists used in research are Ropinirole and Fenoldopam:

  • Ropinirole is a D2 and D3 dopamine receptor agonist used in the treatment of Parkinson’s disease and restless leg syndrome. Ropinirole suppresses oxidative stress and inhibits TDP-43 aggregation by activating the D2 or D3 dopamine receptor.
  • Fenoldopam is a dopamine D1 receptor agonist used in neuroscience research to study dopamine D1-mediated cell signaling and as an anti-hypertensive agent. By activating the D1 dopamine receptor, Fenoldopam enhances vasodilation thus lowering blood pressure.

Explore cell signaling pathways and how these pathways can influence health and disease. Learn more about receptor agonists and how they differ from antagonists.

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