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WKYMVm

Name: WKYMVm
Brand: MM

≥95% (HPLC), Formyl Peptide Receptor-Like 1 Agonist, lyophilized

Synonym(s):

Formyl Peptide Receptor-Like 1 Agonist, WKYMVm, H₂N-WKYMV- D-M-CONH₂, FPRL1 Agonist, WKYMVm, H₂N-WKYMV-D-M-CONH₂, FPRL1 Agonist, WKYMVm

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About This Item

Empirical Formula (Hill Notation):

C₄₁H₆₁N₉O₇S₂

Molecular Weight:

856.11

UNSPSC Code:

12352200

NACRES:

NA.77

Assay:

≥95% (HPLC)

Form:

lyophilized

Quality level:

100

Storage condition:

OK to freeze, desiccated (hygroscopic), protect from light

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Properties

Product Name

Formyl Peptide Receptor-Like 1 Agonist, WKYMVm, The Formyl Peptide Receptor-Like 1 Agonist, WKYMVm controls the biological activity of Formyl Peptide Receptor-Like 1. This small molecule/inhibitor is primarily used for Activators/Inducers applications.

Quality Level

100

assay

≥95% (HPLC)

form

lyophilized

manufacturer/tradename

Calbiochem^®

storage condition

OK to freeze, desiccated (hygroscopic), protect from light

solubility

DMSO: 10 mg/mL

shipped in

wet ice

storage temp.

−20°C

Description

General description

A potent chemoattractant that enhances leukocyte activity via activation of Formyl Peptide Receptor-Like 1 (FPRL1). Shown to activate phospholipase C-mediated inositol phosphate formation in human U266 myeloma cells (EC₅₀ = 510 pM). Also shown to stimulate inositol phosphate formation in U937 and HL60 cells, but has no effect on a variety of other cell lines (e.g. NIH3T3, PC12, Daudi, Sp2, Jurkat, H9, Molt-4, SupT-1, K562, and RBL-2H3). Stimulates phagocyte chemotaxis and [Ca²⁺] flux, and is more effective than fMLP (Cat. No. 05-22-2500) in generating superoxide in human neutrophils. Radioiodinatable at the tyrosine residue.

Biochem/physiol Actions

Cell permeable: no

EC50 = 510 pM in activating phospholipase C-mediated inositol phosphate formation in human U266 myeloma cells

Primary Target
Formyl Peptide Receptor-Like 1

Product does not compete with ATP.

Reversible: no

Packaging

Packaged under inert gas

Physical form

Supplied as a trifluoroacetate salt.

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Other Notes

Bae, Y.S., et al. 2004. J. Immunol.173, 607.
Bae, Y.S., et al. 2003. Mol. Pharmacol.64, 841.
Le, Y., et al. 1999. J. Immunol.163, 6777.
Seo, J.K., et al. 1997. J. Immunol.158, 1895.
Baek, S.H., et al. 1996. J. Biol. Chem.271, 8170.

H-Trp-Lys-Tyr-Met-Val-D-Met-CONH₂

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

Storage Class

11 - Combustible Solids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c