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5.06044

Muscimol

≥99% (HPLC), GABAA receptor agonist, solid

Synonym(s):

Muscimol, GABA A Receptor Agonist, Muscimol, GABAA Receptor Agonist, Muscimol

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About This Item

Empirical Formula (Hill Notation):
C4H6N2O2
CAS Number:
2763-96-4
Molecular Weight:
114.10
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
MFCD00057894
Assay:
≥99% (HPLC)
Form:
solid
Quality level:
100
Storage condition:
OK to freeze, protect from light
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Product Name

Muscimol,

assay

≥99% (HPLC)

Quality Level

100

form

solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze, protect from light

color

white

solubility

water: 100 mM

storage temp.

2-8°C

SMILES string

[N+H3]Cc1[o]nc(c1)[O-]

InChI

1S/C4H6N2O2/c5-2-3-1-4(7)6-8-3/h1H,2,5H2,(H,6,7)

InChI key

ZJQHPWUVQPJPQT-UHFFFAOYSA-N

General description

A constituent and psychoactive ingredient of the mushroom Amanita muscariathat acts as a potent agonist of GABAA receptors (EC50 = 28 µM and 33 µM in neonatal and adult rats, respectively), with preferential efficacy and selectivity to high-affinity receptor subtypes. Shown to be permeate the blood-brain barrier. Impairs associate and memory functions.

Biochem/physiol Actions

Primary Target
GABAA

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Other Notes

Chandra, D., et al. 2010. Neuropsychopharmacology.35, 999.
Fischer, H., et al. 2005. J. Physiol.564, 465.
Ramirez, D.R., et al. 2005. Neurobiol. Learning and Memory.84, 184.
Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Toxic (F)

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pictograms

Skull and crossbones
GHS06

signalword

Danger

Hazard Classifications

Acute Tox. 2 Oral - STOT SE 3

target_organs

Central nervous system

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

hcodes

H300,H336

Storage Class

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

Certificates of Analysis (COA)

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Dev Chandra et al.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 35(4), 999-1007 (2009-12-25)
Muscimol has been regarded as a universal agonist for all gamma-aminobutyric acid type A receptor (GABA(A)-R) subtypes. However, brain regional distribution of muscimol's high-affinity binding sites greatly differs from those of other binding sites of the GABA(A)-R. To test whether
Donna R Ramirez et al.
Neurobiology of learning and memory, 84(3), 184-191 (2005-08-10)
A matching-to-position (MTP) paradigm was altered to influence the type of associations a rat would use to solve the task. Our main behavioral manipulation was the application of the differential outcomes procedure (DOP). The DOP involves correlating each to-be-remembered event
Harald Fischer et al.
The Journal of physiology, 564(Pt 2), 465-474 (2005-02-26)
The effects of gamma-aminobutyric acid (GABA) on the electrophysiological properties of intracardiac neurones were investigated in the intracardiac ganglion plexus in situ and in dissociated neurones from neonatal, juvenile and adult rat hearts. Focal application of GABA evoked a depolarizing

Global Trade Item Number

SKUGTIN
506044000104055977262667