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Merck
CN

5.08161

Sigma-Aldrich

SNC80

Synonym(s):

SNC80, δ Opioid Receptor Agonist, SNC80

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About This Item

Empirical Formula (Hill Notation):
C28H39N3O2
CAS Number:
156727-74-1
Molecular Weight:
449.63
MDL number:
MFCD00672673
UNSPSC Code:
51111800
NACRES:
NA.77

Key Documents

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Assay

≥98% (HPLC)

Quality Level

100

form

solid

potency

0.32 μM IC50

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze
protect from light

color

cream

solubility

1 M HCl: 100 mM
DMSO: 20 mM

storage temp.

−20°C

SMILES string

N3([C@H](CN([C@@H](C3)C)CC=C)C)[C@@H](c2cc(ccc2)OC)c1ccc(cc1)C(=O)N(CC)CC

InChI

1S/C28H39N3O2/c1-7-17-30-19-22(5)31(20-21(30)4)27(25-11-10-12-26(18-25)33-6)23-13-15-24(16-14-23)28(32)29(8-2)9-3/h7,10-16,18,21-22,27H,1,8-9,17,19-20H2,2-6H3/t21-,22+,27-/m1/s1

InChI key

KQWVAUSXZDRQPZ-UMTXDNHDSA-N

Related Categories

General description

A very potent and selective δ opioid receptor agonist (IC50 = 0.32 µM). Shown to induce dose- and time-dependent antinociception after i.c.v., i.th. and i.p. administration in mice. Widely used in studies of depression and inflammatory injuries. It is also reported to be acted upon heteromeric u-d receptors.

Biochem/physiol Actions

Primary Target
Dela opioid receptor

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Other Notes

Pradhan, A., et al., 2013. Mol Pain.9, 8.
Saitoh, A., et al., 2012. Curr. Neuropharmacol.10, 231.
Metcalf. M. et al. 2012. ACS Chem. Neurosci.3, 505.
Bilsky, J., et al. 1995. J. Pharmacol. Exp. Ther.273, 359.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Information

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Certificates of Analysis (COA)

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