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Merck
CN

5.09708

SKF-97541

Synonym(s):

SKF-97541, GABA B Receptor Agonist, SKF-97541, SKF 97541, CGP 35024, 3-APMPA

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About This Item

Empirical Formula (Hill Notation):
C4H12NO2P
CAS Number:
127729-35-5
Molecular Weight:
137.12
MDL number:
MFCD00209879
UNSPSC Code:
12352200
NACRES:
NA.77

Key Documents

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SMILES string

[P](=O)(O)(CCC[N+H3])C

InChI

1S/C4H12NO2P/c1-8(6,7)4-2-3-5/h2-5H2,1H3,(H,6,7)/p+1

InChI key

NHVRIDDXGZPJTJ-UHFFFAOYSA-O

assay

≥98% (TLC)

form

solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze, protect from light

color

white

solubility

water: 100 mM

Quality Level

100

Related Categories

General description

A highly potent agonist of GABAB receptor. Depresses excitatory postsynaptic potentials mediated by glutamate in the striatum, and hyperpolarized neurones in the substantia nigra (IC50 = 92 nM). Shown to be about 10-times more potent than baclofen (Cat. No. 505873). Induces vasodepression in pulmonary vascular bed that is modulated by an ATP-sensitive K+ channel. Induces gastric acid secretion in a dose-dependent manner (0.01 - 3 mg/kg, i.v.) in mice.

Please note that the molecular weight for this compound is batch-specific due to variable water content.

Biochem/physiol Actions

Primary Target
GABAB

Packaging

Packaged under inert gas

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Other Notes

Kaye, A.D., et al. 2004. Anesth. Analg.99, 758.
Piqueras, L., and Martinez, V. 2004. Br. J. Pharmacol.142, 1038.

Seabrook, G.R., et al. 1990. Br. J. Pharmacol.101, 949.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Information

监管及禁止进口产品
This item has

Certificates of Analysis (COA)

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