554412
Tetrodotoxin, Citrate, Fugu sp.
Synonym(s):
TTx, Tetrodotoxin, Citrate, Fugu sp.
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About This Item
Assay:
≥95%
Form:
solid
Storage condition:
OK to freeze
description
Merck USA index - 14, 9246
Quality Segment
assay
≥95%
form
solid
storage condition
OK to freeze
color
white
solubility
H2O: 1 mg/mL
storage temp.
2-8°C
General description
Reversibly blocks Na+ channels, which are essential for the propagation of impulses in excitable membranes. Useful as a marker of Na+ channels in excitable tissues. Inhibits the release of glutamate via Na+-dependent glutamate transporter and prevents veratradine-induced intracellular Ca2+ accumulation (IC50 = 63 nM).
Application
Tetrodotoxin, Fugu sp., CAS 18660-81-6, is a reversible blocker of Na+ channels. Inhibits the release of glutamate via Na+-dependent glutamate transporter.
Biochem/physiol Actions
Target IC50:63 nM Iinhibiting the release of glutamate via Na+-dependent glutamate transporter and prevents veratradine-induced intracellular Ca2+ accumulation
Physical form
Crystalline solid. Contains sodium citrate.
Preparation Note
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C. Activity is destroyed if exposed to alkaline or strongly acidic conditions.
Other Notes
Not available for sale outside of the United States.
Signal Word
Danger
Hazard Codes
Precautionary Statements
Hazard Classifications
Acute Tox. 1 Oral
Storage Class
6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
WGK
WGK 3
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