Tetrodotoxin, Citrate, Fugu sp.

Reversibly blocks Na⁺ channels, which are essential for the propagation of impulses in excitable membranes. Useful as a marker of Na⁺ channels in excitable tissues. Inhibits the release of glutamate via Na+-dependent glutamate transporter and prevents veratradine-induced intracellular Ca²⁺ accumulation (IC₅₀ = 63 nM).

Tetrodotoxin, Fugu sp., CAS 18660-81-6, is a reversible blocker of Na+ channels. Inhibits the release of glutamate via Na+-dependent glutamate transporter.

Target IC₅₀:63 nM Iinhibiting the release of glutamate via Na+-dependent glutamate transporter and prevents veratradine-induced intracellular Ca2+ accumulation

Crystalline solid. Contains sodium citrate.

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C. Activity is destroyed if exposed to alkaline or strongly acidic conditions.

Not available for sale outside of the United States.