Skip to Content
Merck
CN
HomeProductsProtein BiologyBioactive Small MoleculesBioactive Small Molecule Toxins

Bioactive Small Molecule Toxins

A scientist sits at the lab bench wearing lab goggles, a lab coat, and gloves. She is pipetting. Behind her another scientist wearing a lab coat and goggles is using a multichannel pipettor. There are instruments and pipette tips on the right of the image.

Often used by researchers to model diseases or develop antidotes, bioactive small molecule (BSM) toxins are compounds that bind to and disrupt the function of specific target proteins in cells. BSM toxins disrupt protein functions and protein-protein interactions. Because of this, BSM toxins are crucial for helping researchers investigate biological processes and develop novel therapeutics.

We offer an extensive collection of BSM toxins and gain more insight into toxic effect on proteins and cells, model disease mechanisms, and identify therapeutic targets for drug discovery.

Products

Compare
Product Number
Product Name
Product Description
Pricing

Toxins for Research

Bioactive small molecule toxins are harmful substances produced by living organisms that are used in biological research. Researchers have used BSM toxins to probe transmembrane signaling pathways and study membrane protein function. Examples of toxins used in biological research include:

  • Cholera toxin: a member of the AB5-subunit family of toxins that has been used by researchers to study signal transduction mechanisms in cells. Cholera toxin has also been used as a positive control in cyclic AMP (cAMP) assays and as a tissue culture medium supplement when culturing epithelial and primary tumor cell lines.
  • Pertussis toxin: produced by Bordetella pertussis, Pertussis toxin catalyzes the ADP-ribosylation of G-proteins. This prevents G-protein heterotrimers from interacting with their receptors, blocking the downstream signaling pathway. It may have a role in treating autoimmunity, hypertension, and viral infection.
Related Product Categories
Bioactive Small Molecules
Explore 4,000+ potent probes to fine-tune target activity across diverse pathways and major classes. Get expert-designed bioactive small molecules for precise modulation.
Antibodies - Primary, Secondary & Recombinant Monoclonal
Explore our vast selection of primary, secondary, and recombinant monoclonal antibodies for ELISA, Western blot, and immunohistochemistry (IHC).
Proteins & Enzymes
Browse protein, enzyme, and small molecule products for cell biology, culture supplementation, and pathway studies.
Protein Sample Prep
Browse our protein sample purification products, including Roche cOmplete™ protease inhibitors, benzonase, FLAG® tag antibodies, and Amicon® ultra centrifugal filters.
Protein Purification Chromatography
Browse our chromatography products for protein purification, including Protein A, Protein G, Protein L, and the FLAG® system.
Protein Mass Spectrometry
To meet your mass spectrometry needs, explore our comprehensive offering of kits, tagging reagents, calibrants, and MS standards.
Protein Electrophoresis & Western Blotting
Find protein electrophoresis and Western blotting products, including Immobilon membranes, gels, stains, markers, and immunodetection reagents.
Structural Genomics Consortium
Structural Genomics Consortium (SGC) chemical probes for target validation and numerous additional research applications and workflow needs.
Related Applications
Interrogation of Protein Pathways
Explore protein pathway analysis through chemical library screening, investigating protein interactions, and modulating signaling pathways with small molecules.
Gel Electrophoresis
Protein gel electrophoresis is used to separate proteins for purification, characterization, and detection. Methods such as native PAGE, SDS-PAGE, 2D PAGE, and isoelectric focusing (IEF) are used in preparation for downstream applications including Western blotting, mass spectrometry, and proteomic analysis.
Western Blotting
An overview of the principles and applications of Western blotting for protein detection. Includes links to detailed protocols, videos, and other resources for protein extraction, gel electrophoresis, transfer to PVDF or nitrocellulose membranes, and chemiluminescent, colorimetric, and fluorescent detection methods.
Protein Purification
Protein purification techniques, reagents, and protocols for purifying recombinant proteins using methods including, ion-exchange, size-exclusion, and protein affinity chromatography.
Protein Labeling & Modification
Protein labeling applications using enzyme-protein labeling, fluorescent protein labeling, and targeted protein degradation technologies.
Lysis & Protein Extraction
An overview of cell lysis and protein extraction methods including detergent solubilization, freeze-thaw lysis, osmotic shock, sonication, enzymatic cell lysis, and mechanical disruption techniques such as Dounce, Polytron, and mortar and pestle homogenization.
Cancer Research
Cancer research strives to not only identify the cause, but also methods for detection, treatment, and prevention. Learn more about our contributions to cancer research in academic and industrial settings.
Pharmacology & Drug Discovery Research
Pharmacology & Drug Discovery Research
Sign In To Continue

To continue reading please sign in or create an account.

Don't Have An Account?