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T0901317

≥98% (HPLC), liver X receptor agonist, solid

Synonym(s):

T0901317, TO-901317, N-(2,2,2-Trifluoroethyl)-N-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]sulfonamide

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About This Item

Empirical Formula (Hill Notation):
C17H12F9NO3S
CAS Number:
293754-55-9
Molecular Weight:
481.33
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
MFCD03412028
Assay:
≥98% (HPLC)
Form:
solid
Storage condition:
OK to freeze, protect from light
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Product Name

T0901317, A cell-permeable, nonsterol, benzenesulfonamide compound that acts as a highly selective and potent liver X receptor agonist (EC50 of 20 nM for LXRα).

Quality Segment

100

assay

≥98% (HPLC)

form

solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze, protect from light

color

light beige

solubility

DMSO: 50 mg/mL, ethanol: 50 mg/mL

shipped in

wet ice

storage temp.

−20°C

SMILES string

FC(F)(F)CN([S](=O)(=O)c2ccccc2)c1ccc(cc1)C(O)(C(F)(F)F)C(F)(F)F

InChI

1S/C17H12F9NO3S/c18-14(19,20)10-27(31(29,30)13-4-2-1-3-5-13)12-8-6-11(7-9-12)15(28,16(21,22)23)17(24,25)26/h1-9,28H,10H2

InChI key

SGIWFELWJPNFDH-UHFFFAOYSA-N

General description

A cell-permeable, nonsterol, benzenesulfonamide compound that acts as a highly selective and potent liver X receptor agonist (EC50 of 20 nM for LXRα). Reported to induce the expression of genes associated with fatty acid biosynthesis and raise both the levels of serum HDL cholesterol and triglyceride in mice. Also reduces the development of atherosclerosis in LDL receptor-deficient mice and lowers plasma glucose in diabetic rodents.

Biochem/physiol Actions

Cell permeable: yes
EC50 = 20 nM for LXRα
Primary Target
Liver X receptor (LXRα)
Product does not compete with ATP.
Reversible: no

Packaging

Packaged under inert gas

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Other Notes

Terasaka, N., et al. 2003. FEBS Lett.536, 6.
Cao, G., et al. 2002. J. Biol. Chem.278, 1131.
Field, F.J., et al. 2002. Biochem. J.368, 855.
Fukumoto, H., et al. 2002. J. Biol. Chem.277, 48508.
DeBose-Boyd, R.A., et al. 2001. Proc. Natl. Acad. Sci. USA98, 1477.
Repa, J.J., et al. 2000. Science289, 1524.
Schultz, J.R., et al. 2000. Genes Dev.14, 2831.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Harmful (C)

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Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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