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Merck
CN

582243

Sigma-Aldrich

Tetanus Toxin

from Clostridium tetanim, toxin, lyophilized

Synonym(s):

Tetanus Toxin, Clostridium tetani

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About This Item

CAS Number:
676570-37-9
UNSPSC Code:
12352200
NACRES:
NA.77

Key Documents

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Product Name

Tetanus Toxin, Clostridium tetani, Tetanus toxin is produced by Clostridium tetani. Composed of a 100 kDa heavy and a 50 kDa light chain joined by a single interchain disulfide bond.

description

RTECS - XW5807000

Quality Level

100

form

lyophilized

manufacturer/tradename

Calbiochem®

availability

not available in Canada,

storage condition

OK to freeze

solubility

soluble (Please refer to the vial label for lot-specific reconstitution volume.)

storage temp.

2-8°C

General description

Produced by the anaerobic bacillus Clostridium tetani. Tetanus toxin is one of the deadliest toxins known. Composed of two polypeptide chains joined by a single interchain disulfide bond. The heavy chain (100 kDa) participates in binding to the nerve terminals, internalization, retrograde axonal transport, and membrane translocation of the light chain (50 kDa) into the neuronal cytosol. The light chain inhibits neurotransmitter release after reduction of the disulfide bridge.
Tetanus toxin is produced by Clostridium tetani. Composed of a 100 kDa heavy and a 50 kDa light chain joined by a single interchain disulfide bond.

Biochem/physiol Actions

Binds GT1b ganglioside in a hemagglutination assay
Primary Target
Tetanus toxin is one of the deadliest toxins known
Product does not compete with ATP.

Preparation Note

Following reconstitution, refrigerate (4°C). Stock solutions are stable for up to 1 month at 4°C.
Please refer to the vial label for lot-specific reconstitution volume.

Analysis Note

Single band by SDS-PAGE

Other Notes

Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
Montecucco, C., et al. 1994. FEBS Lett. 346, 92.
Wellhöner, H.H., et al. 1987. J. Biol. Chem. 262, 17374.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Highly Toxic (H)

Pictograms

Skull and crossbonesHealth hazard
GHS06,GHS08

Signal Word

Danger

Hazard Statements

H300 + H330,H370

Hazard Classifications

Acute Tox. 1 Oral - Acute Tox. 2 Inhalation - STOT SE 1

Target Organs

Central nervous system

Storage Class Code

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

WGK

WGK 3

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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