681667
Wnt Agonist II, SKL2001
The Wnt Agonist II, SKL2001 controls the biological activity of Wnt. This small molecule/inhibitor is primarily used for Biochemicals applications.
Synonym(s):
Wnt Agonist II, SKL2001, 5-(Furan-2-yl)-N-(3-(1H-imidazol-1-yl)propyl)-1,2-oxazole-3-carboxamide, Wnt Pathway Activator VII
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About This Item
Empirical Formula (Hill Notation):
C14H14N4O3
CAS Number:
Molecular Weight:
286.29
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
Assay:
≥95% (HPLC)
Form:
solid
Storage condition:
OK to freeze, protect from light
Quality Segment
assay
≥95% (HPLC)
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, protect from light
color
pink-red
solubility
DMSO: 100 mg/mL, clear, red
shipped in
ambient
storage temp.
2-8°C
SMILES string
O=C(C1=NOC(C2=CC=CO2)=C1)NCCCN3C=NC=C3
InChI
1S/C14H14N4O3/c19-14(16-4-2-6-18-7-5-15-10-18)11-9-13(21-17-11)12-3-1-8-20-12/h1,3,5,7-10H,2,4,6H2,(H,16,19)
InChI key
PQXINDBPUDNMPE-UHFFFAOYSA-N
General description
A cell-permeable imidazolyl-isoxazolamide compound that upregulates β-catenin-regulated transcription (CRT; Effective conc. 10 - 40 µM) by blocking/disrupting β-catenin and Axin interaction, thereby preventing β-catenin phosphorylation (Ser33/Ser37/Thr41/Ser45) and proteasomal degradation, without affecting the activities of GSK-3α/β or 18 other kinases (≤8.5% inhibition by 10 µM SKL2001). Wnt pathway activation by SKL2001 is shown to effectively promote osteoblastogenesis in both human and murine mesenchymal cultures (10 to 40 µM) as well as suppress MDI- (dexamethasone and insulin) stimulated adipogenesis of murine 3T3-L1 preadipocytes (5 to 30 µM).
Packaging
Packaged under inert gas
Other Notes
Gwak, J., et al. 2012. Cell Res.22, 237.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Standard Handling (A)
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Certificates of Analysis (COA)
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