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Merck
CN

8.51056

HOSu

Novabiochem®

Synonym(s):

HOSu, 1-Hydroxy-2,5-pyrrolidinedione, N-Hydroxysuccinimide, NHS

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About This Item

Empirical Formula (Hill Notation):
C4H5NO3
CAS Number:
Molecular Weight:
115.09
UNSPSC Code:
12352005
EC Index Number:
228-001-3
NACRES:
NA.22
MDL number:
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SMILES string

N1(C(=O)CCC1=O)O

InChI

1S/C4H5NO3/c6-3-1-2-4(7)5(3)8/h8H,1-2H2

InChI key

NQTADLQHYWFPDB-UHFFFAOYSA-N

product line

Novabiochem®

assay

≥99.0% (acidimetric)

form

powder

reaction suitability

reaction type: Coupling Reactions

manufacturer/tradename

Novabiochem®

pH

5-7 (20 °C, 50 g/L in H2O)

mp

93-100 °C

application(s)

peptide synthesis

storage temp.

2-8°C

Quality Level

General description

Reagent used for the synthesis of water-soluble active esters and as an additive to suppress enantiomerization during carbodiimide condensations [1,2].

Associated Protocols and Technical Articles
Guide to Selection of Coupling Reagents

Literature references

[1] G. W. Anderson, et al. (1964) J. Am. Chem. Soc., 86, 1839.
[2] F. Weygand, et al. (1966) Z. Naturforsch., 21, 426.

Analysis Note

Color (visual): white to slight yellow to beige
Appearance of substance (visual): powder
Assay (acidimetric): ≥ 99.0 %
Melting range (lower value): ≥ 95 °C
Melting range (upper value): ≤ 100 °C
Solubility (1 mmole in 2 ml DMF): clearly soluble
Identity (IR): passes test

Other Notes

Replaces: 01-62-0009

Legal Information

Novabiochem is a registered trademark of Merck KGaA, Darmstadt, Germany

pictograms

Corrosion

signalword

Danger

Hazard Classifications

Eye Dam. 1 - Skin Irrit. 2

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable


Certificates of Analysis (COA)

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