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8.52111

Fmoc-Lys(Me)₂-OH HCl

Name: Fmoc-Lys(Me)<sub>2</sub>-OH HCl
Brand: MM

≥95.0% (HPLC), for peptide synthesis, Novabiochem^®

Synonym(s):

Fmoc-Lys(Me)₂-OH HCl, N-α-Fmoc-N-ε-dimethyl-N-L-lysine · hydrochloride

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About This Item

Empirical Formula (Hill Notation):

C₂₃H₂₈N₂O₄ · xHCl

CAS Number:

252049-10-8

Molecular Weight:

396.48 (free base basis)

MDL number:

MFCD05662353

UNSPSC Code:

12352209

NACRES:

NA.22

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Properties

Product Name

Fmoc-Lys(Me)₂-OH HCl, Novabiochem^®

Quality Segment

200

product line

Novabiochem^®

assay

≥95% (TLC), ≥95.0% (HPLC)

form

powder

reaction suitability

reaction type: Fmoc solid-phase peptide synthesis

manufacturer/tradename

Novabiochem^®

application(s)

peptide synthesis

functional group

amine

storage temp.

-10 to -25°C

SMILES string

Cl.N([C@@H](CCCCN(C)C)C(=O)O)C(=O)OCC1c2c(cccc2)c3c1cccc3

InChI

1S/C23H28N2O4.ClH/c1-25(2)14-8-7-13-21(22(26)27)24-23(28)29-15-20-18-11-5-3-9-16(18)17-10-4-6-12-19(17)20;/h3-6,9-12,20-21H,7-8,13-15H2,1-2H3,(H,24,28)(H,26,27);1H/t21-;/m0./s1

InChI key

SJFAFKDBWNFBCC-BOXHHOBZSA-N

Description

General description

A novel derivative for the introduction of dimethyl-lysine during Fmoc SPPS. Ref ^[1] contains methods and protocols for the synthesis of arrays of histone-related peptides containing methylated arginine and lysine-residues.

Associated Protocols and Technical Articles
Cleavage and Deprotection Protocols for Fmoc SPPS
Overcoming Aggregation in Fmoc SPPS

Literature references

^[1] S. Rothbart, et al. (2012) Methods Enzymol., 512, 107.

Analysis Note

Color (visual): white to slight yellow to beige
Appearance of substance (visual): powder
Identity (IR): passes test
Enantiomeric purity: ≥ 99.5 % (a/a)
Purity (TLC(CMA1)): ≥ 95 %
Assay (HPLC, area%): ≥ 95.0 % (a/a)
Solubility (1 mmole in 2 ml DMF): clearly soluble
Acetate (IC): ≤ 1.0 %

To see the solvent systems used for TLC of Novabiochem^® products please click here.

Other Notes

Replaces: 04-12-1269

Legal Information

Novabiochem is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class

11 - Combustible Solids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c