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8.53034

Boc-His(Trt)-OH

Name: Boc-His(Trt)-OH
Brand: MM

≥98.0% (HPLC), for peptide synthesis, Novabiochem^®

Synonym(s):

Boc-His(Trt)-OH, N-α-t.-Boc-N-im-trityl-L-histidine

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About This Item

Empirical Formula (Hill Notation):

C₃₀H₃₁N₃O₄

CAS Number:

32926-43-5

Molecular Weight:

497.58

UNSPSC Code:

12352209

NACRES:

NA.22

MDL number:

MFCD00153307

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Properties

Product Name

Boc-His(Trt)-OH, Novabiochem^®

Quality Segment

200

product line

Novabiochem^®

assay

≥95.0% (acidimetric), ≥98% (TLC), ≥98.0% (HPLC)

form

powder

reaction suitability

reaction type: Boc solid-phase peptide synthesis

manufacturer/tradename

Novabiochem^®

mp

130 °C (decomposition)

application(s)

peptide synthesis

storage temp.

15-25°C

SMILES string

[n]4(cnc(c4)C[C@H](NC(=O)OC(C)(C)C)C(=O)O)C(c3ccccc3)(c2ccccc2)c1ccccc1

InChI

1S/C30H31N3O4/c1-29(2,3)37-28(36)32-26(27(34)35)19-25-20-33(21-31-25)30(22-13-7-4-8-14-22,23-15-9-5-10-16-23)24-17-11-6-12-18-24/h4-18,20-21,26H,19H2,1-3H3,(H,32,36)(H,34,35)/t26-/m0/s1

InChI key

OYXZPXVCRAAKCM-SANMLTNESA-N

Description

General description

A protected histidine derivative for only the critical coupling step in Boc SPPS. After coupling the Boc- and Trt-groups are cleaved simultaneously by TFA.

Associated Protocols and Technical Articles
Cleavage and Deprotection Protocols for Boc SPPS

Analysis Note

Colour (visual): white to off white
Appearance of substance (visual): powder
Identity (IR): passes test
Enantiomeric purity: ≥ 99.0 % (a/a)
Assay (HPLC, area%): ≥ 98.0 % (a/a)
Purity (TLC(011A)): ≥ 98 %
Purity (TLC(0811)): ≥ 98 %
Solubility (1 mmole in 2 ml DMF): clearly soluble
Assay (acidimetric): ≥ 95.0 %
Water (K. F.): ≤ 4.00 %

To see the solvent systems used for TLC of Novabiochem^® products please click here.

Other Notes

Replaces: 04-12-0160

Legal Information

Novabiochem is a registered trademark of Merck KGaA, Darmstadt, Germany

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Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c