Merck
CN
All Photos(1)

Documents

Safety Information

8.55068

Sigma-Aldrich

Hydroxymethyl polystyrene (100-200 mesh), 1% DVB

Novabiochem®

Sign Into View Organizational & Contract Pricing
All Photos(1)
Synonym(s):
Polystyrene-CH 2OH (100-200 mesh)

Quality Level

200

product line

Novabiochem®

form

beads

reaction suitability

reaction type: Boc solid-phase peptide synthesis

manufacturer/tradename

Novabiochem®

application(s)

peptide synthesis

functional group

alcohol

storage temp.

2-30°C

Related Categories

General description

This resin is ideal for the solid phase immobilization of carboxylic acids. Less cross-linking is observed than with Merrifield resin during the attachment of diacids [1]. Reaction with a suitable phosgene equivalent converts this resin to a support suitable for the immobilization of amines [2]. Release of carboxylic acids from this support is normally effected by treatment of the resin with H For TFMSA, or by hydrogenolysis [3]. Alcohols can be liberated by reduction with DIBAL [4] or LiBH4[5]. Methyl esters can be produced by transesterification with MeONa [6] or Ti(OEt)4/CH3CO2Me [7]. Carboxamides are also accessible via Lewis acid catalyzed aminolysis [8].

Associated Protocols and Technical Articles
Protocols for Loading of Peptide Synthesis Resins

Literature references

[1] J. M. Goldwasser, et al. (1978) Can. J. Chem., 56,1562.
[2] D. J. Burdick, et al. (1993) Tetrahedron Lett., 34,2589.
[3] J. M. Schlatter, et al. (1977) Tetrahedron Lett., 2851.
[4] M. J. Kurth, et al. (1994) J. Org. Chem., 59,5862.
[5] J. M. Stewart & J. D. Young in ′Solid Phase Peptide Synthesis, 2nd Ed.′, Rockford, Illinois, Pierce Chemical Company, 1984, pp. 92.
[6] R. Frenette, et al. (1994) Tetrahedron Lett., 35,9177.
[7] L. T. Tietze & A. Steinmetz (1996) Angew. Chem. Int. Ed.Engl., 35, 651.
[8] D. R. Barn, et al. (1996) TetrahedronLett., 37, 3213.

Linkage

Replaces: 01-64-0110

Analysis Note

Color (visual): white to yellow to beige
Appearance of substance (visual): beads
Loading (determined from the substitution of the Fmoc-Leu loaded resin): 0.60 - 1.60 mmol/g
Swelling Volume (in DMF): lot specific result
The polymer matrix is copoly (styrene - 1% DVB) 100 -200 mesh

Legal Information

Novabiochem is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class Code

11 - Combustible Solids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Information

新产品

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

Already Own This Product?

Documents related to the products that you have purchased in the past have been gathered in the Document Library for your convenience.

Visit the Document Library

Difficulty Finding Your Product Or Lot/Batch Number?

Product numbers are combined with Pack Sizes/Quantity when displayed on the website (example: T1503-25G). Please make sure you enter ONLY the product number in the Product Number field (example: T1503).

Example:

T1503
Product Number
-
25G
Pack Size/Quantity

Additional examples:

705578-5MG-PW

PL860-CGA/SHF-1EA

MMYOMAG-74K-13

1000309185

enter as 1.000309185)

Having trouble? Feel free to contact Technical Service for assistance.

Lot and Batch Numbers can be found on a product's label following the words 'Lot' or 'Batch'.

Aldrich Products

  • For a lot number such as TO09019TO, enter it as 09019TO (without the first two letters 'TO').

  • For a lot number with a filling-code such as 05427ES-021, enter it as 05427ES (without the filling-code '-021').

  • For a lot number with a filling-code such as STBB0728K9, enter it as STBB0728 without the filling-code 'K9'.

Not Finding What You Are Looking For?

In some cases, a COA may not be available online. If your search was unable to find the COA you can request one.

Request COA

Protocols

Boc Resin Cleavage and Deprotection

The most popular reagent for cleavage of peptides from Boc-based resins is anhydrous HF. Of all the cleavage procedures HF appears to be the most versatile and least harmful to a wide variety of peptides synthesized on Boc-based resins.

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service