45 kDa (Kikutani, 1987; Aubry, 1987)

CD23 is a 45 kDa type II membrane glycoprotein belonging to the C-type lectin family, and is identical to the low affinity IgE receptor (FceRII) (Kikutani, 1987; Aubry, 1987). CD23 is primarily expressed on B cells and monocytes including a strong expression on EBV-transformed B lymphoblasts (Sarfati, 1997; Sarfati, 1995). CD23 is also present on a large variety of other cells such as T cells, eosinophils, platelets, Langerhans cells, and a subset of thymic epithelial cells (Sarfati, 1995). However, CD23 is absent in a large number of normal non-lymphoid human tissues, such as, central nervous system, endocrine glands, gastrointestinal, respiratory, urinary, and female/male reproductive system, skin, bone, cartilage, connective tissue, muscles, peripheral nerves, vessels, mesothelium, synovium, placenta, and umbilical cord (Pallesen, 1987). Anti-CD23, MHM6, was included in the Second, Third, Fourth, and Fifth International Workshop and Conference on Human Leukocyte Differentiation Antigens, and studies by a number of laboratories confirmed its reactivity with CD23 (Sarfati, 1995).

Antibody recognizes Human CD23 antigen.

EBV-transformed B-lymphoblastoid cells

Detect CD23 using this Milli-Mark Anti-CD23-FITC Antibody, clone MHM6 validated for use in FC.

Research Category
Inflammation & Immunology

Research Sub Category
Immunoglobulins & Immunology

Protein A purified

Purified Mouse monoclonal IgG1 conjugated to FITC in 0.05M Tris-HCl buffer with 1% BSA, Sodium Azide at 0.097% at pH 7.2.

Maintain refrigerated at 2-8°C protected from light in undiluted aliquots for up to 6 months from date of receipt.

Control
human lymphocytes

Evaluated by flow cytometry using human lymphocytes.

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