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FCMAB318PE

Sigma-Aldrich

Milli-Mark® Anti-MAP2-PE Antibody, clone AP20

clone AP20, Milli-Mark®, from mouse

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Synonym(s):
Microtubule-associated protein 2
eCl@ss:
32160702
NACRES:
NA.41

biological source

mouse

Quality Level

100

conjugate

PE

antibody form

purified immunoglobulin

antibody product type

primary antibodies

clone

AP20, monoclonal

species reactivity

human

species reactivity (predicted by homology)

bovine (immunogen homology)

manufacturer/tradename

Milli-Mark®

technique(s)

flow cytometry: suitable

isotype

IgG1

NCBI accession no.

NP_002365

UniProt accession no.

P11137

shipped in

wet ice

target post-translational modification

unmodified

Gene Information

human ... MAP2(4133)

Related Categories

General description

MAP-2 (microtubule associated protein-2) is one of several high molecular weight proteins that play an important role in brain neuron microtubule assembly. In addition to its association with microtubules, MAP-2 associates with neurofilaments and actin filaments suggesting that it may guide interaction among microtubules, other cytoskeletal elements, and cytoplasmic organelles. MAP-2 is a stringent marker for neurons. In addition, MAP-2 displays intracellular specificity. In the central nervous system, MAP-2 is confined to neuronal cell bodies and dendrites. There are exceptions, however, where some axons stain positive for small amounts of MAP-2. MAP-2 is uniformly distributed throughout the cell when first expressed in cultured neurons but becomes selectively localized as dendritic development proceeds. (Caceres, 1986; Dotti, 1987).

Specificity

Antibody recognizes MAP-2.

Immunogen

Recombinant Bovine brain microtubule protein.

Application

Milli-Mark Anti-MAP2-PE Antibody, clone AP20 is an antibody against MAP2 for use in FC.
Research Category
Neuroscience
Research Sub Category
Neuronal & Glial Markers

Quality

Evaluated by flow cytometry using U251 cells

Target description

199.5 kDa Calculated

Physical form

Protein A purified
Purified mouse monoclonal IgG1 conjugated to PE in PBS with 0.1% sodium azide and 15 mg/mL BSA.

Storage and Stability

Maintain refrigerated at 2-8°C protected from light for up to 6 months from date of receipt.

Analysis Note

Control
U251 cells

Legal Information

MILLI-MARK is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Storage Class Code

10 - Combustible liquids

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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Zhijie Chen et al.
Cell death & disease, 13(5), 493-493 (2022-05-25)
Accumulating evidence supports the existence of glioma stem cells (GSCs) and their critical role in the resistance to conventional treatments for glioblastoma multiforme (GBM). Differentiation therapy represents a promising alternative strategy against GBM by forcing GSCs to exit the cell
Dong Woo Kang et al.
The Journal of pathology, 252(3), 304-316 (2020-07-30)
Resistance of glioblastoma to the chemotherapeutic compound temozolomide is associated with the presence of glioblastoma stem cells in glioblastoma and is a key obstacle for the poor prognosis of glioblastoma. Here, we show that phospholipase D1 is elevated in CD44High
Lissette M Andres et al.
ACS chemical biology, 12(8), 2030-2039 (2017-05-26)
The enzymes that determine protein O-GlcNAcylation, O-GlcNAc transferase (OGT) and O-GlcNAcase (OGA), act on key transcriptional and epigenetic regulators, and both are abundantly expressed in the brain. However, little is known about how alterations in O-GlcNAc cycling affect human embryonic

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