MAB4163
Anti-MDR1 Antibody, extracellular human specific Pgp, clone MC57
clone MC57, Chemicon®, from mouse
Synonym(s):
P-glycoprotein, CD243, p170, Pgp
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About This Item
UNSPSC Code:
12352203
NACRES:
NA.42
eCl@ss:
32160702
Clone:
MC57, monoclonal
Species reactivity:
human
Application:
FACS, IHC (p)
Citations:
1
biological source
mouse
Quality Level
antibody form
purified immunoglobulin
antibody product type
primary antibodies
clone
MC57, monoclonal
species reactivity
human
manufacturer/tradename
Chemicon®
technique(s)
flow cytometry: suitable, immunohistochemistry (formalin-fixed, paraffin-embedded sections): suitable
isotype
IgG2aκ
NCBI accession no.
UniProt accession no.
shipped in
wet ice
Gene Information
human ... ABCB1(5243)
Immunogen
Epitope: extracellular human specific Pgp
Living intact human multidrug-resistant cells
Application
Anti-MDR1 Antibody, extracellular human specific Pgp, clone MC57 detects level of MDR1 & has been published & validated for use in FC, IH, IH(P).
Flow Cytometry
Immunohistochemistry
Immunohistochemistry on paraffin sections
Functional Experiments
Optimal working dilutions must be determined by end user.
Immunohistochemistry
Immunohistochemistry on paraffin sections
Functional Experiments
Optimal working dilutions must be determined by end user.
Research Category
Metabolism
Metabolism
Research Sub Category
Toxicology & Drug Resistance
Toxicology & Drug Resistance
Biochem/physiol Actions
MDR-1 clone MC57 recgonizes the inactivated form of Pgp and recognizes the conformational epitope in Immunohistochemistry on paraffin sections.
Physical form
Format: Purified
Purified immunoglobulin from Protein A Sepharose chromatography. Liquid in 0.02M PB, pH 7.6, 0.25M NaCl containing 0.1% sodium azide.
Preparation Note
Maintain at 2-8°C in undiluted aliquots for up to 6 months.
Other Notes
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
Legal Information
CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
Storage Class
12 - Non Combustible Liquids
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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Tsai-Yu Lee et al.
Oncotarget, 7(17), 23512-23520 (2016-03-19)
A tobacco-specific component, 4-methylnitrosamino-1-3-pyridyl-1-butanone (NNK), is a major risk factor for many cancers. Recent reports have demonstrated that NNK exposure may be associated with tumor progression and chemoresistance in certain cancers. However, the underlying NNK-induced mechanism contributing to the aggressiveness
Global Trade Item Number
| SKU | GTIN |
|---|---|
| MAB4163 | 08436037125614 |