Skip to Content

我们计划于北京时间 2025 年 10 月 11 日 11:30 至 10 月 12 日 17:30 进行系统全面维护。此次维护将影响网页端和线下交易,包括在线下单、报价查询、价格及库存查询以及订单状态查询等服务。由此给您带来的不便,我们深表歉意。

Merck
CN

Skip To

MABC32-AF488

Sigma-Aldrich

Anti-p62 (Sequestosome-1) Antibody, clone 11C9.2 Antibody, Alexa Fluor 488 Conjugate

from mouse, ALEXA FLUOR 488

Synonym(s):

EBI3-associated protein of 60 kDa, EBIAP, p60, Phosphotyrosine-independent ligand for the Lck SH2 domain of 62 kDa, Ubiquitin-binding protein p62

Sign Into View Organizational & Contract Pricing

Select a Size

Change View
10 MG
CN¥786.38
50 MG
CN¥3,177.65

About This Item

UNSPSC Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41

CN¥786.38


Estimated to ship onNovember 04, 2025Details


Request a Bulk Order
Technical Service
Need help? Our team of experienced scientists is here for you.
Let Us Assist

biological source

mouse

Quality Level

conjugate

ALEXA FLUOR 488

antibody form

purified immunoglobulin

antibody product type

primary antibodies

clone

monoclonal

species reactivity

mouse, human, rat

technique(s)

flow cytometry: suitable
immunocytochemistry: suitable

isotype

IgM

NCBI accession no.

Related Categories

Compare Similar Items

View Full Comparison

Show Differences

1 of 1

This Item
33746BP11091448559
assay

≥98% (HPLC)

assay

-

assay

-

assay

-

form

powder

form

-

form

powder

form

-

Quality Level

100

Quality Level

100

Quality Level

-

Quality Level

-

storage temp.

−20°C

storage temp.

−20°C

storage temp.

2-8°C

storage temp.

−20°C

solubility

DMSO: 2 mg/mL, clear

solubility

-

solubility

-

solubility

-

color

white to beige

color

-

color

-

color

-

General description

47.7 kDa calculated.
Sequestosome-1 (UniProt: Q13501; also known as EBI3-associated protein of 60 kDa; EBIAP; p60; Phosphotyrosine-independent ligand for the Lck SH2 domain of 62 kDa; Ubiquitin-binding protein p62) is encoded by the SQSTM1 (also known as ORCA, OSIL) gene (Gene ID 8878) in human. Sequestosome-1 is a multifunctional protein that binds ubiquitin and regulates the activation of the nuclear factor kappa-B (NF-kappaB) signaling pathway. It functions as a scaffolding/adaptor protein in concert with TNF receptor-associated factor 6 (TRAF6) to mediate the activation of NF-kappaB in response to upstream signals. Defects in sequestosome-1 are a cause of Paget disease of bone (PDB), a metabolic bone disease affecting the axial skeleton and is characterized by focal areas of increased and disorganized bone turn-over due to activated osteoclasts. Mutations in SQSTM1 gene can lead to frontotemporal dementia and/or amyotrophic lateral sclerosis 3. Frontotemporal dementia is characterized by frontal and temporal lobe atrophy associated with neuronal loss, gliosis, and dementia. Amyotrophic lateral sclerosis is characterized by the death of motor neurons in the brain, brainstem, and spinal cord, resulting in fatal paralysis.

Immunogen

GST-tagged recombinant fragment of 200 amino acids from the internal region of human p62 (Sequestosome-1).

Application

Detect p62 using this mouse monoclonal Anti-p62 (Sequestosome-1) antibody, clone 11C9.2, Alexa Fluor 488 Conjugate, Cat. No. MABC32-AF488, validated for use in Flow Cytometry and Immunocytochemistry.
Immunocytochemistry Analysis: A 1:100 dilution from a representative lot detected p62 Sequestosome-1 in A431 and NIH/3T3 cells.

Flow Cytometry Analysis: A 1:400 dilution from a representative lot detected p62 Sequestosome-1 in one million HeLa cells.

Biochem/physiol Actions

Clone 11C9.2, Alexa Fluor 488 Conjugate detects p62 in HeLa cells.

Physical form

Purified mouse monoclonal antibody IgM in PBS with 1.5% BSA and 0.05% sodium azide.

Analysis Note

Evaluated by Immunocytochemistry in HeLa cells.

Immunocytochemistry Analysis: A 1:100 dilution of this antibody detected p62 (Sequestosome-1) in HeLa cells.

Other Notes

Concentration: Please refer to lot specific datasheet.

Legal Information

ALEXA FLUOR is a trademark of Life Technologies

Not finding the right product?  

Try our Product Selector Tool.

Storage Class Code

12 - Non Combustible Liquids

WGK

WGK 2

Regulatory Information

新产品
This item has

  • Certificates of Analysis (COA)

    Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

    Select a Product Number

    Already Own This Product?

    Find documentation for the products that you have recently purchased in the Document Library.

    Visit the Document Library

    Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

    Contact Technical Service