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Merck
CN

MABF301

Anti-Interleukin-7/IL-7 Antibody, clone 7B1.1

clone 7B1.1, from mouse

Synonym(s):

Interleukin-7, IL-7

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About This Item

UNSPSC Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41

Key Documents

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biological source

mouse

Quality Level

100

conjugate

unconjugated

antibody form

purified immunoglobulin

antibody product type

primary antibodies

clone

7B1.1, monoclonal

species reactivity

human

technique(s)

flow cytometry: suitable
western blot: suitable

isotype

IgG2aκ

NCBI accession no.

NP_000871

UniProt accession no.

P13232

shipped in

wet ice

target post-translational modification

unmodified

Gene Information

human ... IL7(3574)

General description

The protein named IL-7, or interleukin 7 is a hematopoietic growth factor secreted by stromal cell in the bone marrow and thymus but also produced by many other cell types including keratinocytes, epithelial cells, hepatocytes and macrophage/dendritic cells but not by classical lymphocytes. IL7 is a cytokine that has multiple functions and is critical for proper T cell maturation and lymphoid cell survival, and its expression stimulates the proliferation of B cells, T cell and NK cells. IL-7 is detected by cells via its receptor and binding results in a cascade of signals important for T cell development and for T cell survival within the periphery, as well as memory T cells. IL-7 expression is upregulated in various lymphomas and leukemias and because of its effects on T cell development IL-7 is being examined as a therapeutic agent for transplantation studies and even latent viral infection studies.
~ 17 kDa observed

Immunogen

GST-tagged recombinant protein corresponding to human Interleukin-7/IL-7.

Application

Flow Cytometry Analysis: 1 µg of this antibody detected recombinant Interleukin-7/IL-7 in Jurkat T and Raji B lymphocytes.
This Anti-Interleukin-7/IL-7 Antibody, clone 7B1.1 is validated for use in western blotting & flow cytometry for the detection of Interleukin-7/IL-7.

Physical form

Format: Purified

Analysis Note

Evaluated by Western Blotting in Interleukin 7 cell lysate.

Western Blotting Analysis: 0.5 µg/mL of this antibody detected 0.5 µg of recombinant Interleukin-7/IL-7.

Other Notes

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

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Storage Class Code

12 - Non Combustible Liquids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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