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ligand

(Sulfonic acid (strong cationic), t-butyl (weak HIC/hydrophobic))

Quality Level

material

housing (Copolymer of styrene and phenylene ether)
resin (Polyacrylamide hydrogel (microporous polymer) reinforced with polybutylene terephthalate substrate)

sterility

non-sterile

product line

Natrix®

parameter

≤10 MV/min max. flow rate
5 bar pressure
75 psi max. pressure

membrane volume

124 mL , nominal

matrix

Polyacrylamide hydrogel (microporous polymer) reinforced with polybutylene terephthalate substrate base material

pore size

0.4 μm pore size

capacity

>200 mg binding capacity (BSA/ml of membrane)(Up to 1000g/L load capacity in frontal mode)

application(s)

mAb
pharmaceutical
viral therapy

General description

The Natrix® CH Pilot is a membrane chromatography device that can be used for clinical and/or small scale manufacturing activities.
It contains Natrix® CH membrane, a high-capacity cation exchange chromatography membrane.

Application

Frontal displacement
Bind-and-elute

Features and Benefits

  • Unique Selectivity: excellent aggregate removal in flow-through mode.
  • High Binding at Fast Flow-Rates: Natrix® CH membrane has 5x the binding capacity versus the competition at similar residence times.
  • Ready to Process: saves time by eliminating the need for column packing required of traditional resins, simply prime the device and begin purifying.

Legal Information

NATRIX is a registered trademark of Merck KGaA, Darmstadt, Germany

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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