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Merck
CN

01310

N-Acetyl-L-methionine

≥98.5% (T)

Synonym(s):

N-acetyl-L-lysine

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About This Item

Linear Formula:
CH3SCH2CH2CH(NHCOCH3)CO2H
CAS Number:
65-82-7
Molecular Weight:
191.25
UNSPSC Code:
12352209
NACRES:
NA.22
PubChem Substance ID:
329747249
EC Number:
200-617-7
Beilstein/REAXYS Number:
1725552
MDL number:
MFCD00064441

Key Documents

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Product Name

N-Acetyl-L-methionine, ≥98.5% (T)

InChI key

XUYPXLNMDZIRQH-LURJTMIESA-N

InChI

1S/C7H13NO3S/c1-5(9)8-6(7(10)11)3-4-12-2/h6H,3-4H2,1-2H3,(H,8,9)(H,10,11)/t6-/m0/s1

SMILES string

CSCC[C@H](NC(C)=O)C(O)=O

assay

≥98.5% (T)
≥98.5% (TLC)

form

powder or crystals

optical activity

[α]20/D -21.0±1.0°, c = 1% in H2O

reaction suitability

reaction type: solution phase peptide synthesis

mp

103-106 °C (lit.)

solubility

methanol: 50 mg/mL, clear to very slightly hazy, colorless

application(s)

peptide synthesis

Quality Level

100

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Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Certificates of Analysis (COA)

Lot/Batch Number
BCCN2406
BCCG7455
BCCJ4944
BCCF0218
BCCC4556

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Agnieszka Kołodziejczak-Radzimska et al.
Biotechnology progress, 34(3), 767-777 (2018-01-10)
Acylase I from Aspergillus melleus was immobilized on supports consisting of unmodified and modified silica. Modification was performed using 3-aminopropyltriethoxysilane (APTES) and glutaraldehyde (GA). The effectiveness of immobilization was investigated using the standard Bradford method in addition to a number
Mie R Rasmussen et al.
Journal of proteome research, 15(12), 4591-4600 (2016-11-05)
Loss-of-function mutations in the transmembrane ABCC6 transport protein cause pseudoxanthoma elasticum (PXE), an ectopic, metabolic mineralization disorder that affects the skin, eye, and vessels. ABCC6 is assumed to mediate efflux of one or several small molecule compounds from the liver
James B Thoden et al.
Biochemistry, 43(19), 5716-5727 (2004-05-12)
Divergent evolution of enzyme function is commonly explained by a gene duplication event followed by mutational changes that allow the protein encoded by the copy to acquire a new function. An alternate hypothesis is that this process is facilitated when
M Sugumaran et al.
Archives of insect biochemistry and physiology, 38(1), 44-52 (1998-05-20)
Incubation of catechol with mushroom tyrosinase in the presence of N-acetylmethionine resulted in the generation of an adduct. This product was identified to be N-acetylmethionyl catechol, on the basis of spectral characteristics and well-characterized chemical reaction of o-benzoquinone with N-acetylmethionine.
K Lertratanangkoon et al.
Toxicology and applied pharmacology, 122(2), 191-199 (1993-10-01)
Bromobenzene (800 mg/kg, ip) caused severe liver necrosis with massive hemorrhage in the golden Syrian hamster within the first 24 hr. Kidney injury was also observed. Treatment with N-acetylmethionine (NAM) at an ip dose of 1200 mg/kg at 5 hr
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