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03439

Sigma-Aldrich

N-Ethyldiisopropylamine solution

suitable for peptide synthesis, ~2 M in 1-methyl-2-pyrrolidinone

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Synonym(s):
N,N-Diisopropylethylamine, DIPEA, Hünig’s base
Empirical Formula (Hill Notation):
C8H19N
CAS Number:
7087-68-5
Molecular Weight:
129.24
Beilstein:
4124745
MDL number:
MFCD00008868
PubChem Substance ID:
329747633
NACRES:
NA.21

form

liquid

Quality Level

100

concentration

~2 M in 1-methyl-2-pyrrolidinone

impurities

≤0.2% water (KFT)

refractive index

n20/D 1.454

application(s)

peptide synthesis

SMILES string

CCN(C(C)C)C(C)C

InChI

1S/C8H19N/c1-6-9(7(2)3)8(4)5/h7-8H,6H2,1-5H3

InChI key

JGFZNNIVVJXRND-UHFFFAOYSA-N

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General description

N-Ethyldiisopropylamine (EDIA) reacts with monoactivated Michael acceptors to afford symmetrical sulfones.

Application

N,N-Diisopropylethylamine (DIPEA), also known as Hünig′s base, is a sterically hindered amine. It is commonly employed as a base in peptide synthesis. Additionally, DIPEA is also used in the Pd-catalyzed cross-coupling reactions, which include Heck coupling and Sonagashira coupling reactions.

Signal Word

Danger

Hazard Classifications

Acute Tox. 3 Inhalation - Acute Tox. 4 Oral - Aquatic Chronic 2 - Eye Dam. 1 - Flam. Liq. 3 - Repr. 1B - Skin Irrit. 2 - STOT SE 3

Target Organs

Respiratory system

Storage Class Code

3 - Flammable liquids

WGK

WGK 2

Flash Point(F)

73.4 °F

Flash Point(C)

23 °C

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Information

危险化学品

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Eugene F, et al.
The Journal of Organic Chemistry, 59(9), 2599-2603 (1994)
H U Shetty et al.
Journal of the American Society for Mass Spectrometry, 2(2), 168-173 (1991-04-01)
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