04471
(R)-(+)-α-Lipoic acid
analytical standard
Synonym(s):
(R)-(+)-1,2-Dithiolane-3-pentanoic acid, (R)-6,8-Dithiooctanoic acid, (R)-6,8-Thioctic acid
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About This Item
Empirical Formula (Hill Notation):
C8H14O2S2
CAS Number:
Molecular Weight:
206.33
NACRES:
NA.24
PubChem Substance ID:
UNSPSC Code:
85151701
MDL number:
grade
analytical standard
Quality Level
assay
≥98.0% (HPLC)
optical activity
[α]/D +115±5°, c = 1% in ethanol
shelf life
limited shelf life, expiry date on the label
technique(s)
HPLC: suitable, gas chromatography (GC): suitable
mp
48-52 °C (lit.)
application(s)
cleaning products
cosmetics
food and beverages
personal care
format
neat
storage temp.
2-8°C
SMILES string
OC(=O)CCCC[C@@H]1CCSS1
InChI
1S/C8H14O2S2/c9-8(10)4-2-1-3-7-5-6-11-12-7/h7H,1-6H2,(H,9,10)/t7-/m1/s1
InChI key
AGBQKNBQESQNJD-SSDOTTSWSA-N
General description
α-Lipoic acid is an antioxidant which is generally present in plants, animals and many other microorganisms.
Application
α-Lipoic acid has been used as a reference standard for the analysis of α-lipoic acid in human plasma by high performance liquid chromatography coupled to electron capture detector (HPLC-ECD), in various food matrices and dietary supplements by HPLC combined with coulometric electrode array detector (CEAD) as well as electrospray ionization mass spectrometer (ESI-MS).
It may be used as a reference standard for the determination of α-lipoic acid in human urine by isocratic reversed-phase HPLC and in α-lipoic acid capsules by HPLC with chemiluminescence detection.
It may be used as a reference standard for the determination of α-lipoic acid in human urine by isocratic reversed-phase HPLC and in α-lipoic acid capsules by HPLC with chemiluminescence detection.
Packaging
Bottomless glass bottle. Contents are inside inserted fused cone.
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Storage Class
11 - Combustible Solids
wgk
WGK 3
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W Witt et al.
Journal of chromatography. B, Biomedical sciences and applications, 705(1), 127-131 (1998-03-14)
A new method for the quantitation of lipoic acid in plasma and tissues based on the selective precolumn derivatization of thiols with the fluorescent label monobromobimane is described. After extraction with diethyl ether, the dithiolane ring of lipoic acid is
Determination of lipoic acid in human plasma by HPLC-ECD using liquid-liquid and solid-phase extraction: Method development, validation and optimization of experimental parameters.
Khan, et al.
Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences, 878(28), 2782-2788 (2010)
Arjumand I Durrani et al.
Journal of pharmaceutical and biomedical analysis, 45(4), 694-699 (2007-09-21)
Alpha-lipoic acid is an antioxidant used both in the prevention and treatment of various oxidative stress related diseases. It is an important constituent of some dietary supplements and can also be found in plant and animal sources. A rapid method
Global Trade Item Number
| SKU | GTIN |
|---|---|
| H41544-25ML | 04061833794739 |
| H41544-4L | 04061833794746 |
| 8045121000 | 04022536385044 |
| PHR1916-3X1.2ML | 04061835220847 |
| 8045120100 | 04022536385037 |
| 8045126025 | 04022536622002 |
| 8045122500 | 04022536385051 |
| H41544-500ML | 04061833794753 |
| 78891-5ML | 04061837242427 |
| 78891-1ML | 04061832947495 |
| 04471-100MG | 04061838630667 |