09658
Chloro-N,N,N′,N′-tetramethylformamidinium hexafluorophosphate
≥98.0% (T)
Synonym(s):
TCFH
Sign In to View Organizational & Contract Pricing.
Select a Size
Change View
About This Item
Empirical Formula (Hill Notation):
C5H12ClF6N2P
CAS Number:
Molecular Weight:
280.58
UNSPSC Code:
12352101
NACRES:
NA.22
PubChem Substance ID:
MDL number:
Beilstein/REAXYS Number:
7896715
Assay:
≥98.0% (T)
Quality Level
assay
≥98.0% (T)
reaction suitability
reaction type: Coupling Reactions
mp
99-112 °C
application(s)
peptide synthesis
storage temp.
2-8°C
SMILES string
F[P-](F)(F)(F)(F)F.CN(C)\C(Cl)=[N+](\C)C
InChI
1S/C5H12ClN2.F6P/c1-7(2)5(6)8(3)4;1-7(2,3,4,5)6/h1-4H3;/q+1;-1
InChI key
CUKNPSDEURGZCO-UHFFFAOYSA-N
Application
Chloro-N,N,N′,N′-tetramethylformamidinium hexafluorophosphate can be used as a reactant for the synthesis of:
It can also be used as a reagent for the synthesis of:
- Onium salts for use in peptide coupling.
- Benzotriazole based uranium reagent, a safer replacement for coupling reagents.
It can also be used as a reagent for the synthesis of:
- Cancer cell cytotoxins.
- Bioconjugation reagents.
Other Notes
Coupling reagent for peptide synthesis and starting material for preparing other coupling reagents
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
Choose from one of the most recent versions:
Already Own This Product?
Find documentation for the products that you have recently purchased in the Document Library.
A novel family of onium salts based upon isonitroso meldrum's acid proves useful as peptide coupling reagents
El-Faham A, et al.
European Journal of Organic Chemistry, 2010(19), 3641-3649 (2010)
An Efficient Second-Generation Manufacturing Process for the pan-RAF Inhibitor Belvarafenib
Zell, D., et al.
Organic Process Research & Development, 25, 10, 2338-2350 (2021)
N, N, N′, N′-Tetramethylchloroformamidinium hexafluorophosphate (TCFH), a powerful coupling reagent for bioconjugation
Tulla-Puche J, et al.
Bioconjugate Chemistry, 19(10), 1968-1971 (2008)
J. Phillip Kennedy and Craig W. Lindsley
Tetrahedron Letters, 51, 2493-2496 (2010)
TCFH?NMI: Direct Access to N-Acyl Imidazoliums for Challenging Amide Bond Formations
Beutner, Gregory et. al.
Organic Letters, 20(14), 4218?4222-4218?4222 (2018)
Global Trade Item Number
| SKU | GTIN |
|---|---|
| 235857-100G | 04061838785268 |
| 235857-25G | 04061838785275 |
| 8180970050 | 04022536427515 |
| 09658-5G | 04061833354896 |
Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.
Contact Technical Service