09668
N,N,N′,N′-Tetramethyl-O-(N-succinimidyl)uronium hexafluorophosphate
≥99.0% (TLC/N)
Synonym(s):
O-(N-Succinimidyl)-N,N,N′,N′-tetramethyluronium hexafluorophosphate, HSTU
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About This Item
Empirical Formula (Hill Notation):
C9H16F6N3O3P
CAS Number:
Molecular Weight:
359.21
NACRES:
NA.22
PubChem Substance ID:
UNSPSC Code:
12352101
MDL number:
Quality Level
assay
≥99.0% (TLC/N)
form
crystals
reaction suitability
reaction type: Coupling Reactions
mp
218-221 °C (dec.)
solubility
acetonitrile: 0.5 g/mL, slightly hazy, colorless
application(s)
peptide synthesis
storage temp.
−20°C
SMILES string
F[P-](F)(F)(F)(F)F.CN(C)C(\ON1C(=O)CCC1=O)=[N+](\C)C
InChI
1S/C9H16N3O3.F6P/c1-10(2)9(11(3)4)15-12-7(13)5-6-8(12)14;1-7(2,3,4,5)6/h5-6H2,1-4H3;/q+1;-1
InChI key
STWZCCVNXFLDDD-UHFFFAOYSA-N
General description
N,N,N′,N′-Tetramethyl-O-(N-succinimidyl)uronium hexafluorophosphate can be used to prepare N-succinimidyl 4-[18F]fluorobenzoate ([18F]-SFB), a prosthetic group for the fluorination of biomolecules for PET imaging.
Application
Reactant for:
Synthesis of liposomal contrast agents for magnetic resonance imaging
Synthesis of thiol-reactive Cy5 derivatives
Synthesis of protein labeling molecules
Synthesis of liposomal contrast agents for magnetic resonance imaging
Synthesis of thiol-reactive Cy5 derivatives
Synthesis of protein labeling molecules
Other Notes
Coupling reagent for peptide synthesis and the formation of other amides. Even in aqueous solution yields are excellent
signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
Regulatory Information
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Nanoscale research letters, 7(1), 462-462 (2012-08-21)
Ultrasound-sensitive (sonosensitive) liposomes for tumor targeting have been studied in order to increase the antitumor efficacy of drugs and decrease the associated severe side effects. Liposomal contrast agents having Gd(III) are known as a nano-contrast agent system for the efficient
Synthesis of 18F-labeled membrane-penetrating peptide as PET tracer
Tang G and Wang X
Journal of Nuclear Medicine, 49, 97P-97P (2008)
Global Trade Item Number
| SKU | GTIN |
|---|---|
| 09668-5G | 04061833354902 |