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Merck
CN

32002

Sodium 5,5-diethylbarbiturate

purum, ≥99.0% (NT)

Synonym(s):

5,5-Diethylbarbituric acid sodium salt, Barbitone, Sodium barbital, Veronal sodium salt

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About This Item

Empirical Formula (Hill Notation):
C8H11N2NaO3
CAS Number:
144-02-5
Molecular Weight:
206.17
UNSPSC Code:
12161703
NACRES:
NA.77
PubChem Substance ID:
329753946
EC Number:
205-613-9
Beilstein/REAXYS Number:
3921202
MDL number:
MFCD00036203

Key Documents

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InChI key

RGHFKWPGWBFQLN-UHFFFAOYSA-M

InChI

1S/C8H12N2O3.Na/c1-3-8(4-2)5(11)9-7(13)10-6(8)12;/h3-4H2,1-2H3,(H2,9,10,11,12,13);/q;+1/p-1

SMILES string

[Na+].CCC1(CC)C(=O)NC([O-])=NC1=O

grade

purum

assay

≥99.0% (NT)

form

powder or crystals

Quality Level

200

drug control

kontrollierte Droge in Deutschland, regulated under CDSA - not available from Sigma-Aldrich Canada; psicótropo (Spain); Decreto Lei 15/93: Tabela IV (Portugal); Pszichotróp anyag / Psychotropic Substance (Hungary), 78/2022. (XII. 28.) BM rendelet

storage condition

(Tightly closed. Dry.)

technique(s)

GC/MS: suitable, HPLC: suitable, activity assay: suitable

color

colorless

pH

9.0-10.5

mp

>287.1 °C (> 548.8 °F)

solubility

water: soluble 103.1 g/L at 20 °C (68 °F)

density

1.418 g/cm3 at 20 °C ( 68 °F)

suitability

suitable for microbiology, suitable for molecular biology

application(s)

cell analysis

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General description

Sodium 5,5-diethyl barbiturate, also known as Barbital sodium, is a long-acting barbiturate that can significantly depress various metabolic processes at high doses. This weak acid has widespread applications in scientific fields, particularly as a buffering solution in biochemical and biological experiments due to its buffering capabilities. It is particularly well-suited for scenarios requiring lower buffer capacity without compromising pH stability. This buffering effect is achieved through the equilibrium between the acid and its corresponding anion, effectively stabilizing the pH within the desired range. Additionally, Sodium 5,5-diethyl barbiturate has potential applications in histology, and biochemical research, including uses in enzyme assays, cell structure staining, and electrophoresis.

Application

Sodium 5,5-diethyl barbiturate has been used as a component of Michaeli′s buffer, a commonly used buffer solution that helps maintain ideal conditions for histological and histopathological analyses. It is also utilized as a biological buffer in immunoelectrophoresis, hemolytic assays and fixative solutions.

Biochem/physiol Actions

Sedative/hypnotic

Features and Benefits

  • Suitable for electrophoresis and enzymatic assays
  • High purity product for research applications
  • Component of Michaeli′s buffer

Other Notes

For additional information on our range of Biochemicals, please complete this form.
This product is intended for research purposes only, and it is not meant for human consumption.

Legal Information

German
Dieses Produkt fällt unter das Betäubungsmittelgesetz (BtMG). Für eine Bestellung dieses Produktes ist eine Erlaubnis nach § 3 BtMG zwingend erforderlich, es sei denn, es greift eine Ausnahme von der Erlaubnispflicht nach § 4 oder § 26 BtMG.

English
This product is subject to the German Narcotics Act. A permit under Section 3 of the German Narcotics Act is mandatory for ordering this product unless an exemption from the permit requirement under Section 4 or Section 26 of the German Narcotics Act applies.

Disclaimer

Sales restrictions may apply.
Substance of abuse. Regulatory approval may be required for purchase. Comply with applicable laws. Exercise responsible use.

signalword

Warning

pictograms

Health hazardExclamation mark
GHS08,GHS07

Hazard Classifications

Acute Tox. 4 Oral - Eye Irrit. 2 - Repr. 2 - Skin Irrit. 2 - STOT SE 2 - STOT SE 3

target_organs

Nervous system, Respiratory system

Storage Class

13 - Non Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

Regulatory Information

监管及禁止进口产品
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Certificates of Analysis (COA)

Lot/Batch Number
BCCN5568
BCCN1072
BCCL7296
BCCK7194
BCCK2953

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C S Rinder et al.
The Journal of clinical investigation, 96(3), 1564-1572 (1995-09-01)
Complement activation contributes to the systemic inflammatory response induced by cardiopulmonary bypass. At the cellular level, cardiopulmonary bypass activates leukocytes and platelets; however the contribution of early (3a) versus late (C5a, soluble C5b-9) complement components to this activation is unclear.
Y Hiasa et al.
Carcinogenesis, 3(10), 1187-1190 (1982-01-01)
Phenobarbital (PB) and barbital (BB) promoted the development of thyroid tumors in rats treated with a sub-effective dose of N-bis(2-hydroxypropyl)nitrosamine (DHPN) for thyroid tumorigenesis. Rats were given s.c. injections of 70 mg DHPN/100 g body weight once a week for

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