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38370

DIC

≥98.0% (GC), for peptide synthesis

Synonym(s):

N,N′-Diisopropylcarbodiimide

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About This Item

Linear Formula:
(CH3)2CHN=C=NCH(CH3)2
CAS Number:
693-13-0
Molecular Weight:
126.20
NACRES:
NA.22
PubChem Substance ID:
329755678
UNSPSC Code:
12352001
EC Number:
211-743-7
MDL number:
MFCD00065689
Beilstein/REAXYS Number:
878281
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Product Name

DIC, purum, ≥98.0% (GC)

grade

purum

Quality Segment

assay

≥98.0% (GC)

form

liquid

reaction suitability

reaction type: Coupling Reactions

refractive index

n20/D 1.433 (lit.)

bp

145-148 °C (lit.)

density

0.815 g/mL at 20 °C

application(s)

peptide synthesis

functional group

amine

SMILES string

CC(C)N=C=NC(C)C

InChI

1S/C7H14N2/c1-6(2)8-5-9-7(3)4/h6-7H,1-4H3

InChI key

BDNKZNFMNDZQMI-UHFFFAOYSA-N

Gene Information

human ... EPHX2(2053)
mouse ... Ephx2(13850)

General description

N,N′-Diisopropylcarbodiimide (DIC) is a carbodiimide used as a coupling reagent in the synthesis of amides, peptides, ureas, heterocycles, and unsymmetrical carbodiimides. It is also used in the polymerization reactions as an activator.

Application

N,N′-Diisopropylcarbodiimide can be used:
  • To synthesize lanthanide (Ln) guanidinate complexes via insertion of carbodiimide into the Ln-N bond of lanthanocene secondary amido complexes.
  • To facilitate the cyclization of N-(β-Hydroxy)amides to form 2-oxazolines.
  • To synthesize 1-isopropyl-2-alkoxycarbonyl-3-isopropyliminio-aziridine by reacting with alkyl diazoacetates in the presence of transition metal salts.

DIC can be used as:
  • A coupling reagent for the synthesis of various esters and amides by treating carboxylic acids with phenols and amines respectively.
  • A reagent for the conversion of alcohols to aldehydes or ketones in the presence of DMSO via modified Moffatt-type oxidation reaction.
  • A reagent to facilitates the preparation of alkyl halides from corresponding alcohols via the formation of o-alkylisourea.

Alternative to dicyclohexylcarbodiimide in peptide synthesis.

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Signal Word

Danger

Hazard Classifications

Acute Tox. 1 Inhalation - Eye Dam. 1 - Flam. Liq. 3 - Resp. Sens. 1 - Skin Sens. 1

Storage Class

3 - Flammable liquids

WGK

WGK 3

Flash Point (°F)

91.4 °F

Flash Point (°C)

33 °C

PPE (personal protective equipment)

Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter

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