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410225

Glycine

Name: Glycine
Brand: SIAL

ACS reagent grade, ≥98.5%, powder, crystals or granules

Synonym(s):

Aminoacetic acid, Aminoethanoic acid, Glycocoll

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About This Item

Linear Formula:

NH₂CH₂COOH

CAS Number:

56-40-6

Molecular Weight:

75.07

NACRES:

NA.21

PubChem Substance ID:

24865701

eCl@ss:

32160406

UNSPSC Code:

12352209

EC Number:

200-272-2

MDL number:

MFCD00008131

Beilstein/REAXYS Number:

635782

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Product Name

Glycine, ACS reagent, ≥98.5%

grade

ACS reagent

Quality Level

200

assay

≥98.5%

form

powder, crystals or granules

impurities

H₂SO₄, passes test (darkened), Hydrolyzable subsances, passes test

ign. residue

≤0.1%

color

white

pKa (25 °C)

(1) 2.35, (2) 9.60, 2.35

mp

240 °C (dec.) (lit.)

anion traces

chloride (Cl^-): ≤0.005%, sulfate (SO₄^2-): ≤0.005%

cation traces

NH₄⁺: ≤0.005%, heavy metals: ≤0.002% (by ICP)

application(s)

peptide synthesis

functional group

amine, carboxylic acid

SMILES string

NCC(O)=O

InChI

1S/C2H5NO2/c3-1-2(4)5/h1,3H2,(H,4,5)

InChI key

DHMQDGOQFOQNFH-UHFFFAOYSA-N

Gene Information

rat ... Grin2a(24409)

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Related Categories

Building Blocks, Resins, and Coupling Reagents for GLP-1 Synthesis

Amino Acids, Resins & Reagents for Peptide Synthesis

Chemistry & Biochemicals

General description

Glycine is the simplest amino acid building block.

Application

Glycine has been used in whole-cell patch clamp recording to measure inward NMDA (N-methyl-D-aspartate) currents. It has also been used as a model organic system in crystallography to demonstrate a novel acoustic nebulization platform.

Biochem/physiol Actions

Glycine is a non-essential amino acid. Influx of calcium through the cell membrane is mediated by glycine-gated channel. Glycine participates in the synthesis of porphyrins, purine and serine. It also serves as a competitive agonist for glutamate in binding to the NMDA (N-methyl-D-aspartate) receptors. Glycine synthesis might be increased in rapidly proliferating cancer cells, due to increased demand for the amino acid.

Inhibitory neurotransmitter in spinal cord, allosteric regulator of NMDA receptors.

Storage Class

11 - Combustible Solids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Certificates of Analysis (COA)

Lot/Batch Number

0000520867

0000476860

0000473224

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Controversial Effects of D-Amino Acid Oxidase Activator (DAOA)/G72 on D-Amino Acid Oxidase (DAO) Activity in Human Neuronal, Astrocyte and Kidney Cell Lines: The N-methyl D-aspartate (NMDA) Receptor Hypofunction Point of View

Vinita Jagannath

Frontiers in Molecular Neuroscience (2017)

A Novel Acoustomicrofluidic Nebulization Technique Yielding New Crystallization Morphologies

Heba Ahmed

Advanced Materials, 30(3) (2018)

Amino acids: metabolism, functions, and nutrition

Guoyao Wu

Amino Acids, 37(1), 1-17 (2009)

Metabolite Profiling Identifies a Key Role for Glycine in Rapid Cancer Cell Proliferation

Mohit Jain

Science, 336(6084), 1040-1044 (2012)

Glycine receptor antibodies in PERM and related syndromes: characteristics, clinical features and outcomes.

Alexander Carvajal-González et al.

Brain : a journal of neurology, 137(Pt 8), 2178-2192 (2014-06-22)

The clinical associations of glycine receptor antibodies have not yet been described fully. We identified prospectively 52 antibody-positive patients and collated their clinical features, investigations and immunotherapy responses. Serum glycine receptor antibody endpoint titres ranged from 1:20 to 1:60 000.

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Global Trade Item Number

SKU	GTIN
410225-1KG	04065273586763
410225-50G	04061835555123
410225-250G	04061835555116

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