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Merck
CN

68790

Drometrizole trisiloxane

analytical standard

Synonym(s):

2-(2H-Benzotriazol-2-yl)-4-methyl-6-{2-methyl-3-{1,3,3,3-tetramethyl-1-[(trimethylsilyl)oxy]disiloxanyl}propyl}phenol, Silatrizole

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About This Item

Empirical Formula (Hill Notation):
C24H39N3O3Si3
CAS Number:
155633-54-8
Molecular Weight:
501.84
UNSPSC Code:
41116107
NACRES:
NA.24
PubChem Substance ID:
329760825
MDL number:
MFCD22373626
Beilstein/REAXYS Number:
11343300

Key Documents

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InChI

1S/C24H39N3O3Si3/c1-18-14-20(15-19(2)17-33(9,29-31(3,4)5)30-32(6,7)8)24(28)23(16-18)27-25-21-12-10-11-13-22(21)26-27/h10-14,16,19,28H,15,17H2,1-9H3

SMILES string

CC(Cc1cc(C)cc(c1O)-n2nc3ccccc3n2)C[Si](C)(O[Si](C)(C)C)O[Si](C)(C)C

InChI key

HUVYTMDMDZRHBN-UHFFFAOYSA-N

grade

analytical standard

assay

≥98.0% (HPLC)

shelf life

limited shelf life, expiry date on the label

technique(s)

HPLC: suitable, gas chromatography (GC): suitable

application(s)

cleaning products
cosmetics
environmental
food and beverages
personal care

format

neat

Quality Level

100

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General description

Drometrizole trisiloxane (DRT) belongs to the lipophilic benzotriazole derivative class of compounds commonly utilized in sunscreen cosmetics.

Application

DRT may be used as a reference standard for the determination of DRT in:
  • Active pharmaceutical ingredients (APIs), formulations and stability samples by reversed phase ultra-high performance liquid chromatography (RP-UPLC) coupled to electrospray ionization-quadrupole time-of-flight tandem mass spectrometry (ESI-QTOF-MS/MS).
  • Suncare formulations by high performance liquid chromatography (HPLC) with ultraviolet (UV) detection.
  • Cosmetic products by LC-UV.
  • Sewage sludge samples by QuEChERS (quick, easy, cheap, effective, rugged, and safe) extraction procedure and gas chromatography combined with MS/MS.

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Packaging

Bottomless glass bottle. Contents are inside inserted fused cone.

Other Notes

Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial.

hcodes

H413

Hazard Classifications

Aquatic Chronic 4

Storage Class

10 - Combustible liquids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
BCCM6795
BCCH9053
BCCD0345
BCBV5651
BCBS1141V

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A reliable and environmentally-friendly liquid-chromatographic method for multi-class determination of fat-soluble UV filters in cosmetic products.
Chisvert A, et al.
Analytica Chimica Acta, 790(1-2), 61-67 (2013)
A Sensitive, Stability indicating UPLC method for the identification and characterization of forced degradation products for Drometrizole Trisiloxane through MSn studies.
Babu MA, et al.
Journal of Applied Pharmaceutical Science, 8(06), 065-074 (2018)
Development and optimization of a QuEChERS-GC-MS/MS methodology to analyse ultraviolet-filters and synthetic musks in sewage sludge.
Ramos S, et al.
The Science of the Total Environment, 790(1-2), 61-67 (2018)
Determination of sixteen UV filters in suncare formulations by high-performance liquid chromatography.
Schakel DJ, et al.
Journal of Chromatography A, 1049(1-2), 127-130 (2004)

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