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Merck
CN

72795

Butein

analytical standard

Synonym(s):

1-(2,4-Dihydroxyphenyl)-3-(3,4-dihydroxyphenyl)-2-propen-1-one, 2′,3,4,4′-Tetrahydroxychalcone

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About This Item

Empirical Formula (Hill Notation):
C15H12O5
CAS Number:
487-52-5
Molecular Weight:
272.25
NACRES:
NA.24
PubChem Substance ID:
329764364
UNSPSC Code:
85151701
EC Number:
207-659-5
MDL number:
MFCD00017300

Key Documents

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Product Name

Butein, analytical standard

InChI

1S/C15H12O5/c16-10-3-4-11(14(19)8-10)12(17)5-1-9-2-6-13(18)15(20)7-9/h1-8,16,18-20H/b5-1+

InChI key

AYMYWHCQALZEGT-ORCRQEGFSA-N

SMILES string

OC1=CC(O)=C(C(/C=C/C2=CC(O)=C(O)C=C2)=O)C=C1

grade

analytical standard

assay

≥98.0% (HPLC)

shelf life

limited shelf life, expiry date on the label

impurities

≤10% water (calc. from elemental analysis)

application(s)

food and beverages

format

neat

storage temp.

2-8°C

Quality Level

100

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Biochem/physiol Actions

Inhibits EGFR and Src tyrosine kinase activities; inhibits cAMP-dependent PDE-IV. Induces apoptosis in B16 melanoma cells and HL-60 human leukemia cells.

Other Notes

Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
BCCN5931
BCCK0282
BCCH0484
BCCF5571
BCCD6739

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Rianne D Stowell et al.
Nature neuroscience, 22(11), 1782-1792 (2019-10-23)
Microglia are the brain's resident innate immune cells and also have a role in synaptic plasticity. Microglial processes continuously survey the brain parenchyma, interact with synaptic elements and maintain tissue homeostasis. However, the mechanisms that control surveillance and its role

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