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Merck
CN

73235

Sennoside C

analytical standard

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About This Item

Empirical Formula (Hill Notation):
C42H40O19
CAS Number:
37271-16-2
Molecular Weight:
848.76
MDL number:
MFCD28902518
UNSPSC Code:
85151701
NACRES:
NA.24

Key Documents

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grade

analytical standard

Quality Level

100

Assay

≥98% (HPLC)

shelf life

limited shelf life, expiry date on the label

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

application(s)

food and beverages

format

neat

storage temp.

2-8°C

SMILES string

OC[C@H]1O[C@@H](Oc2cccc3[C@@H]([C@@H]4c5cccc(O[C@@H]6O[C@H](CO)[C@@H](O)[C@H](O)[C@H]6O)c5C(=O)c7c(O)cc(cc47)C(O)=O)c8cc(CO)cc(O)c8C(=O)c23)[C@H](O)[C@@H](O)[C@@H]1O

InChI

1S/C42H40O19/c43-11-14-7-18-26(16-3-1-5-22(30(16)34(50)28(18)20(46)8-14)58-41-38(54)36(52)32(48)24(12-44)60-41)27-17-4-2-6-23(59-42-39(55)37(53)33(49)25(13-45)61-42)31(17)35(51)29-19(27)9-15(40(56)57)10-21(29)47/h1-10,24-27,32-33,36-39,41-49,52-55H,11-13H2,(H,56,57)/t24-,25-,26?,27?,32-,33-,36+,37+,38-,39-,41-,42-/m1/s1

InChI key

ZFWOUNNKSHIAFK-JZOSXXJUSA-N

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General description

Sennoside C is an anthraquinone glycoside, belonging to the group of sennosides, widely found in Senna plant. It is commonly used worldwide as a natural laxative.

Application

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.
Sennoside C may be used as an analytical reference standard for the quantification of the analyte in Senna and formulations using high-performance liquid chromatography.

Packaging

Bottomless glass bottle. Contents are inside inserted fused cone.

Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Statements

H302

Precautionary Statements

P264 - P270 - P301 + P312 - P501

Hazard Classifications

Acute Tox. 4 Oral

Storage Class Code

11 - Combustible Solids

WGK

WGK 2

Flash Point(F)

651.9 °F

Flash Point(C)

344.4 °C

Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number
BCCL5484
BCCG7983
BCCB9724
BCBW0836
BCBT8676

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T Yagi et al.
The Journal of pharmacy and pharmacology, 49(1), 22-25 (1997-01-01)
This study aimed to explore the mechanism involved in the synergistic purgative action of aloe-emodin anthrone and rhein anthrone, the active metabolites of sennoside C. Aloe-emodin anthrone and rhein anthrone, and their equimolar mixture, induced excretion of an approximately equal
Potentiating effect of sennoside C on purgative activity of sennoside A in mice.
K Kisa et al.
Planta medica, 42(3), 302-303 (1981-07-01)
Analytical studies on the active constituents in crude drugs. IV. Determination of sennosides in senna and formulations by high-performance liquid chromatography
Hayashi I-S, et al.
Chemical & Pharmaceutical Bulletin, 28(2), 120-128 (1980)
Next generation sequencing and transcriptome analysis predicts biosynthetic pathway of sennosides from Senna (Cassia angustifolia Vahl.), a non-model plant with potent laxative properties
Reddy RRN, et al.
Testing, 10(6), 120-128 (2015)
K Yamauchi et al.
The Journal of pharmacy and pharmacology, 44(12), 973-976 (1992-12-01)
Sennosides A and C directly injected into the caecum of mice showed equal purgative activity. Intracaecal administration reduced time to onset of diarrhoea induced by sennoside C from about 3 h after oral administration to about 24 min. At 2.3

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