75047
Piperine
analytical standard
Synonym(s):
1-Piperoylpiperidine
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About This Item
Empirical Formula (Hill Notation):
C17H19NO3
CAS Number:
Molecular Weight:
285.34
UNSPSC Code:
85151701
NACRES:
NA.24
PubChem Substance ID:
EC Number:
202-348-0
Beilstein/REAXYS Number:
90741
MDL number:
grade
analytical standard
Quality Level
assay
≥97.0% (HPLC)
shelf life
limited shelf life, expiry date on the label
technique(s)
HPLC: suitable, gas chromatography (GC): suitable
mp
131-135 °C (lit.)
application(s)
cleaning products
cosmetics
flavors and fragrances
food and beverages
personal care
format
neat
storage temp.
2-8°C
SMILES string
O=C(\C=C\C=C\c1ccc2OCOc2c1)N3CCCCC3
InChI
1S/C17H19NO3/c19-17(18-10-4-1-5-11-18)7-3-2-6-14-8-9-15-16(12-14)21-13-20-15/h2-3,6-9,12H,1,4-5,10-11,13H2/b6-2+,7-3+
InChI key
MXXWOMGUGJBKIW-YPCIICBESA-N
General description
Piperine is a naturally occurring bioactive alkaloid in pepper, which imparts pungency and bitter flavor to it. It has demonstrated health benefits and exhibits therapeutic properties, which include its role as an antimicrobial, antioxidant, antifungal, immunomodulatory and hepatoprotective agent. The inhibition of drug-metabolizing enzymes in hepatic and pulmonary tissues, and the enhancement of drug bioavailability by this compound are reported. It is also found to play an important role in reducing blood glucose, cholesterol and triglycerides.
Piperine is an amide isolated from the plant, Piper longum. It is a known inhibitor of hepatic and intestinal glucuronidation. Piperine is found to exhibit pharmacological properties like antitumor, antipyretic and anti-inflammatory activities.
Application
Piperine may be used as an analytical reference standard for the quantification of the analyte in:
- Human plasma using high-performance liquid chromatography coupled to electrospray ionization tandem mass spectrometry (HPLC-ESI-MS/MS).
- Piper nigrum extract using reversed phase high pressure liquid chromatographic method with UV detection (RP-HPLC-UV).
- Food products using high-performance liquid chromatography with diode array detection (HPLC-DAD).
Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.
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signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral - Aquatic Chronic 2
Storage Class
11 - Combustible Solids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
涉药品监管产品
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A liquid chromatography method for the simultaneous determination of curcumin and piperine in food products using diode array detection
Nagappan VK , et al.
Asian Journal of Research in Chemistry, 2(2), 115-118 (2009)
Preliminary study on inhibition of genotoxicity by piperine in mice
Selvendiran K, et al.
Fitoterapia, 76(3-4), 296-300 (2005)
Validated HPLC?MS/MS method for simultaneous determination of curcumin and piperine in human plasma
Wang M-X, et al.
Tropical Journal of Pharmaceutical Research, 11(4), 621-629 (2012)
Global Trade Item Number
| SKU | GTIN |
|---|---|
| 471208-1L | 04061832359564 |
| 301264-400G | 04061826665275 |
| 395064-100ML | 04061831982930 |
| 395064-800ML | 04061836826772 |
| 395072-100ML | 04061831982947 |
| 395072-800ML | 04061837673016 |
| 301264-100G-EU | 04061833465011 |
| 301264-100G | 04061826665268 |
| 471208-2.5L | 04061837673580 |
| 471208-100ML | 04061837673573 |
| 471208-500ML | 04061837673603 |
| 724033-100G | 04061832861210 |
| 724033-PZ | 04061833108598 |
| 75047-50MG | 04061832898131 |